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The War of Unification was a conflict involving members of the Isu, the First Civilization, that started at some point prior to the year 1923 Isu Era (c. 75383 BCE).

The conflict saw the creation of numerous Pieces of Eden, such as the Swords of Eden by Hephaestus with the purpose of ending the war, though this resulted in numerous deaths.

In response to the rising mortality rate, the Isu scientist and Hephaestus' apprentice, Consus, created the Shrouds of Eden to act as medicinal field kits capable of treating casualties of the war.

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