Vatican may refer to:
- Vatican Vault, a large chamber constructed by the Isu, located beneath the Sistine Chapel in the Vatican.
- Vaticano district, a district of Rome, located on the west bank of the Tiber River.
- Sistine Chapel, the chapel of the Pope in Rome, and center of the Catholic faith.
- St. Peter's Basilica, the central place of worship for the Pope, located in the Vaticano District of Rome.