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The Truth: Ezio died of a heart attack, Ubisoft even confirmed it. The guy who sat down next to him was just a random guy, who reminded Ezio of his teenage years. (Always chasing after women.) The guy got up and left because he saw Ezio wasn't feeling well. There wasn't any poison involved, and the, "Templar insignia" on his wrist has nothing to do with it. Ezio knew he was on his way out, that's why he wrote his death letter before he left for Florence with his family. We all saw Ezio's decaying health condition throughout the movie (His coughing). It was at it's worst point when he arrived in Florence with his family (His wheezing). He also knew his passing was coming because when his wife said something about Ezio staying home, he said,…Read more >