I began replaying AC2, and a thought occurred during the Glyph-puzzles. In the fifth, the Instruments of Power, one of the images is Eugene Delacroix's painting, which in-game is given only the description of "King Ferdinand and Queen Isabella, Spain", depicting Christopher Columbus' return. I know it's just speculation, but that painting's presence seems to hint to the identity of 'Queen Isabella'. Unless, of course, she's not a person at all, but a ship... :p

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