A certain Italian, Harry Walnut, I believe, said Rome wasn't built in a day. But It can certainly be destroyed in less than one; and that's what it looks like in ASSASSIN'S CREED BROTHERHOOD. No, this is not the sequel to Assassin's Creed II. They say it is not Assassin's Creed III even though it's the third installment of the Series and takes place after the events of Assassin's Creed II. In 1499, Ezio is still pleasing the Ladies, but things haven't gone his way. His beloved town of Monteriggioni is becoming Detroit in 1948, and his uncle... Well, lets just say it isn't looking good for him.
Anyway, Rome is now becoming Detroit from a new age, 2005. Ezio has travelled to Rome for Revenge. He wants his Arch enemy dead, he wants the Templars of Rome Dead, he wants their house burnt to the ground! Ezio's got to be nuts, and to beat his enemy then he'll need a crew as nuts as he is. So now Ezio is trying to kill all of the Templars, and trying not to make Rome like what Cesare Borgia did to Monteriggioni.
So lets wait to find out if Ezio wins, even though he is NUTS. Or finally, Ezio dies a madman.