Being a leatherworker, Jeffers owned a small leather shop on Whitechapel's Fleet Street, selling items such as leather coats and bags. One of his frequent customers was his deliveryman, George, who often bought gifts for his sweetheart Joanna.
Unbeknownst to everyone, Jeffers was also a serial killer, murdering several people over a few months. He then flayed them to use their skin as leather, ground their bones into manure, and sold their meat to the local bakery for meat-pies.
In 1868, Jeffers was questioned by Detective Murphy, who had received tips about the disappearances and was now investigating them. Feeling that the detective was coming too close to the truth, Jeffers killed him, using his skin to make a handbag, which George went on to gift to Joanna.
Jeffers discovered that George suspected the truth behind the products, followed him home, and killed him with one of his leatherworking tools. Not long after, Jeffers was again question about the disappearances, this time by the Assassins Jacob and Evie Frye. Confronted with enough evidence to implicate him, Jeffers gleefully confessed to his crimes, before being taken away by the Metropolitan Police Service.