751th century BC
- Adam and Eve, two human slaves, escaped from the First Civilization city Eden with an Apple of Eden.
- Humanity rose up in rebellion against the First Civilization, starting a ten-year long war. Jupiter, Juno and Minerva retreated to the Grand Temple to find a solution from the impending solar flare, trying six non-succesful options.
750th century BC
- A solar flare struck the Earth, exterminating most of the Earth's population; less than ten thousand humans, and far fewer members of the First Civilization, survived the catastrophe. Humanity and the First Civilization started working together to rebuild civilization.
6th century BC
- September: Darius I claimed the throne of Persia from the usurper Bardiya with aid from the Templars.
5th century BC
- Pythagoras, a Greek scholar, established the religious movement of Pythagoreanism, which later influenced Hermeticism.
- August 4: King Xerxes I of Persia, a Templar puppet, was killed by the Assassin Darius; this assassination became the first recorded use of the hidden blade.
4th century BC
- June 13: Alexander the Great, ruler of the Macedonian Empire and a Templar ally, died after having been fatally poisoned by the Assassin Iltani.
3rd century BC
- September 10: Qin Shi Huang, the first Emperor of China and a Templar puppet, was killed by the Assassin Wei Yu with a spear for his tyranny over China.
1st century BC
- March 15: Gaius Julius Caesar was killed by twenty-three Roman Senators, secret members of the Assassin Brotherhood, under leadership of Marcus Junius Brutus, after he had been named dictator of the Roman Republic under influence of the Templars.
- October 23: Marcus Junius Brutus committed suicide when he was nearly defeated by Marcus Antonius and Octavian at the Battle of Philippi. The Assassins only temporarily managed to revive Brutus with the Shroud of Eden.
- August 12: Cleopatra, Queen of Egypt and a Templar puppet, was killed by the Assassin Amunet using a poisonous asp.
- April 3: Jesus Christ, the wielder of the Shroud of Eden, was crucified by the Templars, who proceeded to take possession of the artifact.
- January 24: Roman emperor Caligula, a Templar puppet, was killed by the Assassin Leonius using a dagger.
- Construction began on the Colosseum in Rome under emperor Vespasian, atop an ancient First Civilization vault.
- The Gallo-Roman Assassin Aquilus was taken captive by Romans under command of general Gracchus. An army of Alemanni soldiers, led by the Assassin Accipiter, defeated the Roman legion and saved Aquilus.
- Aquilus acquired the Ankh from Accipiter and transported it to his family's villa in Lugdunum, where his father Lucius tasked him with the assassination of the local priest Faustinus, who had betrayed the Assassins.
- The Roman senator and Templar Caïus Fulvus Vultur killed Lucius and his servant Weke to obtain the Ankh, and brought it with him to Rome.
- Aquilus killed Caïus Fulvus Vultur inside his villa in Rome, and took the Ankh back to his home in Lugdunum, where he watched a recording made by his father using the artifact.
- Accipiter brokered a truce with the Prefect of Lugdunum to spare the city from being conquered and sacked by the Alemanni.
- Aquilus and his wife Valeria were captured by Roman soldiers and transported to be executed in Rodumna. Aquilus was killed by one of the soldiers when the convoy was ambushed by Accipiter.
- May 12: Pope Sylvester II, a Templar leader, was branded a heretic and burned at the stake for promoting scientific development during the Middle Ages.
- July 15: An army of Crusaders captured the city of Jerusalem, marking the end of the First Crusade and the start of a Crusader presence in the Holy Land for over two centuries.
- January 13: The Order of the Knights Templar was publicly recognized during the Council of Troyes, with Hugues de Payens serving as the first public Grand Master. With help from Bernard de Clairvaux, de Payens formed the Latin Rule.
- Sultan Salāḥ ad-Dīn laid siege to the Levantine Assassins' fortress in Masyaf. Acting on information received from Ahmad Sofian, the Mentor Rashid ad-Din Sinan tasked Umar Ibn-La'Ahad with infiltrating the enemy camp, where he left a note tied to a dagger in Salāḥ ad-Dīn's tent.
- Šihāb ad-Dīn, uncle to Salāḥ ad-Dīn, brokered a truce with the Assassins on the condition that Umar Ibn-La'Ahad be executed for taking the life of a Ayyubid nobleman during his infiltration of their camp. Against Sinan's will, Umar voluntarily had his life taken.
- Ahmad Sofian committed suicide inside the quarters of Umar Ibn-La'Ahad's son Altaïr because of his remorse over giving Umar's name to the Saracens while in their captivity.
- July 4: The Battle of Hattin occurred between the Crusader Kingdom of Jerusalem and the Saracen forces of Saladin, resulting in a Saracen victory. King Guy of Lusignan, Templar Grand Master Gerard de Ridefort and Raynald of Châtillon were taken as prisoners and later released.
- Altaïr Ibn-La'Ahad assassinated Haras, an Assassin-turned Templar, in Masyaf fortress during an attack by the Templars, saving the life of Rashid ad-Din Sinan. Altaïr was elevated to the rank of Master Assassin.
- The Knights Templar besieged the Assassins' fortress in Aleppo, on orders of their de facto leader Lord Basilisk, though the Assassins were able to fend off the attack.
- Rashid ad-Din Sinan tasked Altaïr Ibn-La'Ahad with finding the Chalice, an ancient artifact that held powers similar to a Piece of Eden.
- Altaïr Ibn-La'Ahad traveled to Damascus and assassinated the Templar merchant Tamir, and the Templar Knight Alaat on behalf of Fajera, who handed him one of the keys to the Temple of the Sand, where the Chalice was supposedly held.
- Roland Napule was assassinated by Altaïr Ibn-La'Ahad in Tyre on orders of the local rafiq Hamid. Altaïr retrieved a second key to the Temple of the Sand from one of Napule's captives.
- Altaïr Ibn-La'Ahad retrieved the third key to the Temple of the Sand from Templar leader Basilisk at a party in Jerusalem, acting upon information gained from the rafiq Kadar and the nobleman Ayman.
- Altaïr Ibn-La'Ahad killed the Master of the Templars' Jerusalem Tower and his student while attempting to retrieve a map of the Temple of the Sand.
- Lord Basilisk attempted to stop the Siege of Acre by poisoning Acre's water supply, though the plan was thwarted by Altaïr Ibn-La'Ahad. Altaïr bested Basilisk in combat, but spared his life in exchange for the location of the Chalice.
- Altaïr Ibn-La'Ahad killed Harash, the second-in-command of Rashid ad-Din Sinan, after hearing of his betrayal from Adha, who revealed herself to be the Chalice.
- Lord Basilisk was killed by Altaïr Ibn-La'Ahad in the harbor of Tyre, after the Templars captured Adha. Despite Basilisk's death, the Templars shipped Adha away from Tyre.
- Altaïr Ibn-La'Ahad and the brothers Malik and Kadar Al-Sayf infiltrated the Jerusalem Vault to retrieve an Apple of Eden. After encountering Templars led by Grand Master Robert de Sable, Kadar was killed and Malik lost his left arm, though the latter brought the artifact back to Masyaf.
- The Assassins fended off an attack by the Knights Templar led by Robert de Sable. Rashid ad-Din Sinan demoted Altaïr Ibn-La'Ahad for betraying the three tenets of the Assassin's Creed.
- July–September: Altaïr Ibn-La'Ahad killed eight of his nine Templar assassination targets – Tamir, Garnier de Naplouse, Talal, Abu'l Nuqoud, William of Montferrat, Majd Addin, Sibrand and Jubair al Hakim – in the cities of Damascus, Acre and Jerusalem, to restore his rank of Master Assassin.
- September: Altaïr Ibn-La'Ahad attempted to assassinate Robert de Sable at the funeral of Majd Addin in Jerusalem, but discovered that Robert had assigned Maria Thorpe as his decoy. Altaïr spared Maria's life.
- September 7: Crusader and Saracen forces clashed at the Battle of Arsuf, where the Crusaders emerged victorious. The Assassin Altaïr Ibn-La'Ahad fought his way across the battlefield to the Crusader camp, where he challenged Robert de Sable to a duel, in which de Sable was killed.
- Rashid ad-Din Sinan was killed by Altaïr Ibn-La'Ahad after betraying the Assassin Brotherhood by brainwashing his subjects using the Apple of Eden to make them worship him.
- Abbas Sofian sparked a minor civil war among the Assassins against Altaïr Ibn-La'Ahad. Abbas stole their Mentor's Apple of Eden, though it slowly began killing him, until he was saved by Altaïr.
- Altaïr Ibn-La'Ahad succeeded Rashid ad-Din Sinan as Mentor of the Levantine Brotherhood of Assassins, after persuading the Assassins of his capabilities.
- Grand Master Armand Bouchart, who succeeded Robert de Sable, relocated the Knights Templar to Cyprus. During their relocation from Acre, Altaïr Ibn-La'Ahad led an Assassin attack on Acre's harbor and captured Maria Thorpe.
- Altaïr Ibn-La'Ahad killed the Templar captain Frederick "the Red" in Limassol Castle, after establishing contact with Alexander of Limassol, the local leader of the resistance against the Knights Templar.
- Altaïr Ibn-La'Ahad rescued Maria Thorpe from imprisonment by Armand Bouchart, who did not intend to break the Latin Rule by conspiring with women. The two traveled by boat to Kyrenia.
- Jonas, a merchant from Kyrenia, was killed by Altaïr Ibn-La'Ahad on behalf of a a Templar agent posing as the Kyrenia resistance leader Barnabas, triggering a riot among the populace.
- Moloch, leader of a local group of fanatics and a Templar ally, was killed by Altaïr Ibn-La'Ahad in Kantara Castle, acting upon information gained from Maria Thorpe and resistance soldier Markos.
- The Dark Oracle, a former Cypriot noblewoman, provided the Knights Templar with the locations of resistance members. Altaïr Ibn-La'Ahad rescued the members from captivity, and killed the Dark Oracle in Buffavento Castle.
- Maria Thorpe and Altaïr Ibn-La'Ahad infiltrated Saint Hilarion Castle, where Altaïr killed Moloch's sons, the Templars Shalim and Shahar, eradicating the Templar presence in Kyrenia.
- The Knights Templar moved all their artifacts out of the Templar Archive in Limassol to an unknown location, on orders of Grand Master Armand Bouchart.
- Grand Master Armand Bouchart was killed by Altaïr Ibn-La'Ahad, during a duel between the two in the Templar Archive.
- July 12: The Crusaders conquered and sacked the city of Constantinople, ending the Fourth Crusade. During the siege, Altaïr Ibn-La'Ahad, who had come to Constantinople to spread the influence of the Assassins, was forced to retreat from the city.
- The First Barons' War started between the forces of King John of England, supported by the Assassin William of Cassingham, and the rebelling English Barons, led by the Assassin Robert Fitzwalter and aided by France.
- Altaïr Ibn-La'Ahad, his wife Maria and their son Darim left Masyaf to oppose the rise of the Mongol Empire and eliminate Genghis Khan. Malik Al-Sayf was left to lead the Assassins, with help of Darim's younger brother Sef.
- Sef Ibn-La'Ahad, son of Altaïr Ibn-La'Ahad, was killed by the apprentice Swami on orders of Abbas Sofian, in an attempt to claim control of the Levantine Assassins.
- Malik Al-Sayf was framed for the murder of Sef Ibn-La'Ahad by Abbas Sofian, who placed a council in charge of the Levantine Assassins, with himself at its head.
- February: Jochi Khan, first son of the Mongol warlord Genghis Khan, was fatally poisoned by the Assassin Darim Ibn-La'Ahad.
- August: Genghis Khan, ruler of the Mongol Empire, was killed by the Assassin Darim Ibn-La'Ahad in China, after he fell off his horse when it was shot by Qulan Gal.
- Altaïr Ibn-La'Ahad, Maria Thorpe and their son Darim returned to Masyaf, where they were informed of the ruling council. Darim traveled to Alamut to meet with Sef's wife and children.
- Malik Al-Sayf was rescued by Altaïr Ibn-La'Ahad from Masyaf's dungeons, from whom Altaïr heard the truth about his son Sef's death. In Altaïr's and Maria's absence, Malik was beheaded by Swami.
- Altaïr Ibn-La'Ahad and Maria Thorpe confronted Abbas Sofian in Masyaf's fortress. Upon being taunted by Swami, Altaïr used the Apple to force Swami to kill himself. In the ensuing frenzy, Swami fatally stabbed Maria. Altaïr escaped Masyaf with help from his son Darim.
- Altaïr exiled himself to the Assassins' fortress at Alamut, while Abbas usurped the title of Mentor. At Alamut, Altaïr made several discoveries and inventions using the Apple of Eden, and discovered Memory Seals in the Temple beneath the fortress.
- December 11: Ögedei Khan, the second Great Khan of the Mongol Empire and the third son of Genghis Khan, was killed by the Assassin Nergüi.
- The merchant Mukhlis from the brigands Bayhas and his henchmen outside Masyaf by Altaïr Ibn-La'Ahad, who had returned from his self-imposed exile in Alamut.
- Altaïr Ibn-La'Ahad started gaining the support of the Levantine Assassins and Masyaf's villagers in attempting to take back the declining Brotherhood under Abbas Sofian, and befriended Malik Al-Sayf's son Tazim.
- Abbas Sofian was killed by Altaïr Ibn-La'Ahad using the Hidden Gun, during a non-violent assault on Masyaf fortress by Altaïr and his supporters. Altaïr was welcomed as Mentor of the Levantine Brotherhood of Assassins.
- Construction began on a hidden library beneath the fortress of Masyaf, under orders of Altaïr Ibn-La'Ahad.
- An unidentified Egyptian Assassin obtained the Scepter of Aset and brought it to the rebelling Mamluks, who used it to remove the reigning Ayyubid dynasty from power and found the Bahri dynasty.
- Batu Khan, founder of the Golden Horde, a sub-khanate of the Mongol Empire, was murdered on orders of his subordinate Alexander Nevsky.
- December 15: Hülegü Khan destroyed the Assassin fortress of Alamut, during his destruction of the Levantine Assassins' holdings.
- January: Niccolò and Maffeo Polo arrived in Masyaf on invitation of their friend Darim Ibn-La'Ahad, and became acquainted with the Mentor Altaïr Ibn-La'Ahad.
- July: Altaïr Ibn-La'Ahad and his son Darim began training Niccolò and Maffeo Polo in the ways of the Assassin Brotherhood, in the hopes that they would help spread their ideology to the west. Niccolò started writing his journal, The Secret Crusade, detailing Altaïr's life.
- August 12:
- Hülegü Khan began the Mongol siege on the Assassin fortress at Masyaf, ultimately rendering the fortress abandoned.
- Altaïr Ibn-La'Ahad guided Niccolò and Maffeo Polo out of the city and granted them his Codex, the Masyaf Keys and several books, and allowed the rest of the Brotherhood to escape.
- Altaïr Ibn-La'Ahad passed away after locking himself inside his library with the Apple of Eden and imprinting his last memory into the sixth Memory Seal.
- August 14: Niccolò and Maffeo Polo were attacked by a Mongol raiding party in the Syrian countryside, and lost Altaïr Ibn-La'Ahad's Codex.
- January 1: Niccolò and Maffeo Polo established an Assassins Guild in Constantinople, in the Byzantine Empire.
- January: Niccolò and Maffeo Polo scattered Altaïr Ibn-La'Ahad's books around various landmarks in Constantinople, and hid the five Masyaf Keys in underground tombs located beneath the city.
- Niccolò and Maffeo Polo left Constantinople to journey to the Mongol Empire to retrieve Altaïr Ibn-La'Ahad's Codex, without succes.
- November 14: Alexander Nevsky, a Russian leader and Templar ally, was killed by the Assassin Nergüi for his alliance with the Golden Horde and influence over the Mongol Empire.
- February 8: Hülegü Khan was killed by the Mongolian Assassin Nergüi, out of retribution for the destruction of Masyaf and the Levantine Assassins.
- Niccolò and Maffeo Polo returned to their home in Venice, Italy, where they established an Assassins Guild.
- November: Marco Polo left on a journey to Asia with his father Niccolò and uncle Maffeo, intent on retrieving the codex of Altaïr Ibn-La'Ahad.
- May: Marco Polo retrieved Altaïr Ibn-La'Ahad's Codex from Kublai Khan's summer palace in Shangdu, bringing it with him when he returned to Venice several years later.
- July 7: Pope Benedict XI died after being poisoned by his political rival Guillaume de Nogaret, the councillor to King Philip IV of France and Mentor of the French Assassins.
- October 13: The Knights Templar were branded heretics by King Philip IV of France, under influence of Mentor Guillaume de Nogaret, and their Temple in Paris was besieged. One Templar Knight hid their Sword of Eden and Codex Pater Intellectus, but was killed by the Assassin Thomas de Carneillon.
- March 18: Jacques de Molay, the last publicly recognized Grand Master of the Knights Templar and Sage, was burned at the stake alongside Geoffroi de Charney. Before his death, de Molay sent nine of his most trusted men across the known world to continue the Order's objectives underground.
- September 14: Dante Alighieri was killed by the Templars, revealing their continued existence to the Assassins.
- Domenico Auditore and his wife and son attempted to bring Altaïr Ibn-La'Ahad's Codex to Spain, but were attacked in the Otranto harbor by pirates employed by the Templars; his wife did not survive the encounter.
- January: Marco Polo, and later Domenico Auditore's father, were killed by the Templars.
- Domenico Auditore bought and renovated the villa in Monteriggioni, renaming it Villa Auditore. Monteriggioni became the headquarters of the Italian Assassins.
- Lukas Zurburg was saved by the Assassins from a road thief while travelling from Essen to Adendorf. Zurburg joined the Assassin Brotherhood.
- The Templars stole the Scepter of Aset from the reigning Bahri dynasty of Egypt.
- The Egyptian Assassin Numa Al'Khamsin traveled to Cairo and interrogated Bachir Al-Djallil, a merchant in collusion with the Templars, who revealed the artifact was taken to Karnak, before he was killed by Numa.
- June 7: The reigning Bahri Sultan of Egypt, Al-Nasir Muhammad, was killed by his servant Leila, a secret Templar agent.
- Numa Al'Khamsin and his apprentice Ali Al-Ghrabe recovered the Scepter of Aset, disassembled in an Ankh-shaped box, from the Templars in Karnak.
- The Brothers of the Cross, a secret Templar organization, traveled through the Holy Roman Empire looking for the Ankh, pretending to offer people protection from the Black Death.
- The Brothers of the Cross and Lukas Zurburg mysteriously vanished from public view.
- The Assassins stole the Shroud of Eden from Geoffroy de Charny, a French knight and Templar, and replaced it with a forgery. A member of the Auditore family ordered the Shroud to be buried beneath the Villa Auditore.
- June 2: A Templar expedition led by the Templar Knights Henry Sinclair and James Gunn landed on North American soil.
- July 17: Zhu Di became the Yongle Emperor, with aid from the Templars, founding the Ming dynasty and succeeding the Jianwen Emperor.
- July: The Chinese imperial army arrested and executed thousands of people, on orders of the Yongle Emperor, on suspicions of being Assassins; the Assassin leader Fang Xiaoru was killed during the purge. Li Tong managed to escape the Assassin headquarters in Beijing with an Apple of Eden.
- The Chinese admiral Zheng He started his fifth exploration voyage, discovering lands in Southeast Asia, Africa and the Middle East, ahead of European explorers.
- August 12: The Yongle Emperor was assassinated by the Assassin Li Tong while trying to suppress a rebellion in the Gobi Desert.
- May 30: Jeanne d'Arc was burned at the stake by the English, an act that was orchestrated by the Templars to obtain the Sword of Eden she had in her possession.
- June 29: The Battle of Anghiari was fought between the Florentine and Milanese armies. A 6-year old Mario Auditore alerted the Florentine commander Micheletto Attendolo of a surprise attack by the Milanese, resulting in a Florentine victory.
- Ilario Auditore, an old friend of Cosimo de' Medici, was succeeded as Gonfaloniere of Florence by Luca Albizzi.
- May 29: Sultan Mehmet II of the Ottoman Empire conquered Constantinople, the capital of the Byzantine Empire, utilizing an Apple of Eden, effectively destroying the Byzantine Empire.'
- September: Monteriggioni was besieged by the Florentine army led by Federico da Montefeltro. Under Mario Auditore's leadership, Monteriggioni managed to fend off the siege.
- October 1: Mario Auditore discovered the Shroud of Eden beneath the Villa Auditore in Monteriggioni; while exploring the crypts, Mario lost an eye upon triggering a trap.
- Lorenzo de' Medici, son of Cosimo de' Medici and the future leader of Florence, was saved by the Assassin Giovanni Auditore da Firenze from drowning in the Arno in Florence.
- December: Vlad Tepes, the ruler of Wallachia and a Templar, was killed during an Assassin attack led by Ottoman Assassin leader Ishak Pasha.
- December 26: Galeazzo Maria Sforza, the Duke of Milan, was killed by Templar conspirators Giovanni Andrea Lampugnani, Carlo Visconti and Gerolamo Olgiati. Visconti and Olgiati were captured and later hanged, while Lampugnani was killed by a Moorish guard.
- December 29: Giovanni Auditore da Firenze and his sons Federico and Petruccio were hanged in front of the Palazzo della Signoria, on false accusations of treason against Florence, by secret Templar Uberto Alberti.
- December 31: Gonfaloniere Uberto Alberti was killed by Ezio Auditore da Firenze for betraying the Auditore family, during an exposition of Andrea del Verrocchio's work.
- January: Ezio Auditore and his mother Maria and sister Claudia left Florence and moved to Monteriggioni to live with their uncle Mario in the Villa Auditore.
- April 14: Vieri de' Pazzi, a Templar, was killed by his childhood rival Ezio Auditore da Firenze in San Gimignano in Tuscany for conspiring with the Templars.
- April 26:
- Lorenzo de' Medici, ruler of Florence, and his brother Giuliano were attacked by the Templar Pazzi conspirators, resulting in the death of Giuliano. Lorenzo was saved and brought to safety by Ezio Auditore da Firenze, who had spied on the conspirators' meeting with aid from La Volpe.
- Francesco de' Pazzi was killed by Ezio Auditore da Firenze. Francesco's body was hung from the Palazzo della Signoria, while his uncle Jacopo de' Pazzi was rallying a mob against the Medici.
- Antonio Maffei, a Pazzi conspirator, was killed by Ezio Auditore da Firenze atop San Gimignano's tallest tower.
- April 12: Francesco Salviati, a Pazzi conspirator, was killed by Ezio Auditore da Firenze in his villa near San Gimignano.
- May 3: Bernardo Baroncelli, a Pazzi conspirator, was killed by Ezio Auditore da Firenze near the city walls of San Gimignano.
- Stefano da Bagnone, a Pazzi conspirator, was killed by Ezio Auditore da Firenze in the Monte Oliveto Maggiore outside San Gimignano.
- January 3: Jacopo de' Pazzi was killed by Ezio Auditore da Firenze, after he was mortally wounded by Grand Master Rodrigo Borgia and Emilio Barbarigo during a Templar meeting in the Antico Teatro Romano for his failure during the Pazzi Conspiracy.
- March 3: Ezio Auditore da Firenze and Leonardo da Vinci sailed to Venice, with aid from Caterina Sforza, where Ezio would form an alliance with the local thieves guild.
- May 3: Sultan Mehmet II of the Ottoman Empire passed away, leaving his two sons Bayezid and Cem, a Templar, competing for the throne. Though Cem managed to secure their father's Apple of Eden, Bayezid secured the Ottoman throne.
- June: Prince Cem hid his Apple of Eden in the Templar Archive on Cyprus after realizing the artifact refused to communicate with him, so that the European Templars could find it.
- June 29: Prince Cem met the Knights Hospitaller on Rhodes; however, he was betrayed by the Hospitallers and sent to be imprisoned in Europe, and became acquainted with Grand Master Rodrigo Borgia in Italy.
- September 11: Emilio Barbarigo, leader of the Venetian merchant guild and Templar, was killed by Ezio Auditore da Firenze with aid from members of the local thieves guild, namely their leader Antonio de Magianis, Rosa and Ugo.
- September 14: Carlo Grimaldi was killed by Ezio Auditore da Firenze, who infiltrated the Palazzo Ducale with Leonardo da Vinci's flying machine, for poisoning Doge Giovanni Mocenigo.
- February 15: Marco Barbarigo, the Templar Doge of Venice, was killed by Ezio Auditore da Firenze after infiltrating the Doge's Carnevale feast with help from Sister Teodora.
- July 11:
- Silvio Barbarigo and Dante Moro, members of the Templar Order, were killed by Ezio Auditore da Firenze with aid from Bartolomeo d'Alviano's mercenaries.
- The Italian Templars left Venice to retrieve the Piece of Eden from Cyprus, after ascertaining its location from Altaïr Ibn-La'Ahad's Codex pages.
- June 16: The army of Lambert Simnel, a pretender to the English throne and Templar puppet, was defeated by King Henry VII of England, and Simnel was imprisoned.
- June 25: Ezio Auditore da Firenze stole the Apple of Eden from the Templars in Venice, who had just returned from Cyprus. After a confrontation with Grand Master Rodrigo Borgia, Ezio was formally inducted into the Assassin Order by his allies from the courtesans, thieves and mercenaries guilds.
- July 7:
- The brothers Checco and Ludovico Orsi attacked the city of Forlì on orders of Grand Master Rodrigo Borgia, after its ruler Caterina Sforza had hired the Orsi brothers to kill her Templar husband Girolamo Riario.
- Ludovico and Checco Orsi were killed by Ezio Auditore da Firenze, who had come to Forlì with Niccolò Machiavelli to give the Apple of Eden to Caterina Sforza for safekeeping; Ezio passed out after being wounded by Checco, and lost the artifact to the monk Girolamo Savonarola.
- The explorer Christoffa Corombo was saved by Ezio Auditore da Firenze from being killed by Borgia guards during a scheduled meeting with Rodrigo Borgia, to prevent Corombo from discovering the Americas.
- Ezio Auditore da Firenze forged an alliance with Christoffa Corombo and his friend Luis de Santángel, secretly an Assassin, and traveled with them to Spain to stop the persecution of Spanish Assassins by the Spanish Inquisition, influenced by the Templars.
- Ezio Auditore da Firenze killed the Inquisitors Gaspar Martinez in Barcelona and Pedro Llorente in Zaragoza after establishing contact with the Assassin Raphael Sánchez, saving the captured Assassins in the process.
- King Muhammad XII of Granada was rescued from the Templars amidst a Spanish siege on Granada. Ezio convinced Muhammad to make peace with Queen Isabela and end the Templar-driven war.
- The Inquisitor Juan de Marillo was killed by Ezio Auditore da Firenze after attempting to round up and execute the Spanish Assassins in Granada.
- Christoffa Corombo was saved by Ezio Auditore da Firenze from a Templar attack while en route to France, after being lured there by the Templars with a false promise of the French King financing his journey.
- January: King Ferdinand II of Aragon and Queen Isabella I of Castile agreed to finance half of Christoffa Corombo's journey to discover an alternate sea route to Asia, with the Spanish Assassins covering the other half of the costs.
- Ezio Auditore da Firenze infiltrated the palace of Grand Inquisitor Tomás de Torquemada with the intent of assassinating Torquemada, but ultimately spared his life after he escaped and Ezio discovered that he was nothing more than a puppet to Rodrigo Borgia.
- August 11: Grand Master Rodrigo Borgia was elected as the new head of the Catholic Church, after purchasing votes from the other cardinals, and became known as Pope Alexander VI.
- October 12: Christoffa Corombo's fleet discovered the Americas, and landed on the island of Guanahani, inhabited by the Taíno.
- November 9: Girolamo Savonarola stirred the Florentines into rebelling against Piero de' Medici using the Apple of Eden. The Medici were exiled and Savonarola became the city's de facto leader.
- Marcello Savonarola, cousin to Girolamo Savonarola, was saved in Florence by Ezio Auditore da Firenze from Borgia guards.
- Piero de' Medici was saved by Girolamo Savonarola's followers in Venice. With Ezio Auditore da Firenze, Piero took down his attackers and a corrupt herald.
- February 25: Prince Cem was killed in Capua by the Assassins, who believed the Borgia were planning to use Cem to conquer Constantinople.
- June 14: Juan Borgia was killed by the courtesan Fiora Cavazza on orders of his brother Cesare Borgia, allowing the latter to become Captain General of the Papal Armies.
- Ezio Auditore da Firenze killed Girolamo Savonarola's nine lieutenants, in an effort to remove Savonarola's control over the Florentine population and regain the Apple of Eden.
- March 3: Giovanni Borgia was born to Lucrezia Borgia and either her brother Cesare Borgia or the Assassin Perotto Calderon, but suffered from a life-threatening deformation. Calderon stole the Shroud of Eden from his Brothers in Agnadello to save his son's life. The Assassins subsequently killed Perotto.
- May 23:
- Girolamo Savonarola was captured by an angry Florentine mob in front of the Palazzo Pitti. Ezio regained the Apple of Eden, after it was stolen by a Borgia soldier.
- Girolamo Savonarola was killed by Ezio Auditore da Firenze out of mercy while being burned at the stake in front of the Palazzo della Signoria in Florence.
- September 17: Tomás de Torquemada, Grand Inquisitor of Spain, was killed by the Assassins for his tyranny over the Spanish people.
- November 23: Perkin Warbeck, a Templar, was hanged by King Henry VII of England for his attempt to claim the English throne.
- December 28:
- Pope Alexander VI was defeated by the Assassin Ezio Auditore da Firenze in a fistfight at the entrance of the Vatican Vault; realizing that killing Rodrigo would not bring his family back, Ezio chose to spare the Pope's life.
- Ezio Auditore da Firenze received a message from the Precursor Minerva for Ezio's descendant Desmond Miles, after opening the vault doors using his Apple of Eden and the Papal Staff.
- January 2: Monteriggioni was besieged and destroyed by the Papal Army under orders of Cesare Borgia, who executed the captured Assassin leader Mario Auditore and took possession of the Assassins' Apple of Eden; Ezio Auditore was severely wounded during the siege, and Caterina Sforza was captured
- January: Niccolò Machiavelli became the leader of the Italian Assassins and set up headquarters on Tiber Island in Rome to fight the Borgia. Ezio Auditore da Firenze joined him and later set up an underground network in the city led by his sister Claudia, La Volpe and Bartolomeo d'Alviano.
- May: Nicolaus Copernicus was saved from Borgia attacks by Ezio Auditore da Firenze, after Copernicus betrayed the Templar Order by making his scientific discoveries public.
- December 16/17: The Assassins destroyed several warehouses and factories in Calicut owned by Pedro Álvares Cabral, a Portuguese explorer tasked with eliminating the local Assassins Guild. The population of Calicut rose in rebellion against Cabral, and he fled the city.
- June 30: Caterina Sforza escaped her imprisonment by Lucrezia Borgia in the Castel Sant'Angelo with the help of the Assassin Ezio Auditore da Firenze.
- September 20: Agostino Barbarigo, the Doge of Venice and an Assassin ally, died after having been poisoned by an Assassin team consisting of Francesco Vecellio, Cipriano Enu and Tessa Varzi for making deals with the Borgia.
- Ezio Auditore da Firenze destroyed the war machines that Leonardo da Vinci designed on orders of Cesare Borgia, on Da Vinci's own request.
- Yusuf Tazim met with a contingent of Venetian Assassins in an joint effort to steer the Ottoman–Venetian War to a peaceful end.
- October 18: The University of Wittenberg opened its doors. Its founder, Friedrich der Weise, previously received a large anonymous donation from the Assassins, stolen from the Templars.
- November 1: Vasco da Gama bombarded the city of Calicut for two days in retaliation for the Assassins routing Pedro Álvares Cabral. After Gama left the city, the Assassins eliminated his remaining commanders.
- December 31: Vitellozzo Vitelli and Oliverotto da Fermo were killed by Micheletto Corella for rebelling against Cesare Borgia.
- August 1: Juan Borgia the Elder was killed by Ezio Auditore da Firenze at Juan's Pagan party in Rome.
- Baron Octavian de Valois was killed in the Castra Praetoria in Rome by Ezio Auditore da Firenze, with aid from Bartolomeo d'Alviano's mercenaries.
- Micheletto Corella's attempt on Pietro Rossi's life was twarted by Ezio Auditore da Firenze, though he ultimately spared Micheletto's life.
- Ezio Auditore da Firenze was promoted to Mentor of the Italian Brotherhood of Assassins, and Claudia Auditore da Firenze was inducted into the Brotherhood.
- August 18: Pope Alexander VI was killed by his son Cesare Borgia, using the poisoned apple that the Pope intended to kill his son with for his reckless behaviour; Ezio Auditore da Firenze retrieved the Apple of Eden from the courtyard of Saint Peter's Basilica ahead of Cesare.
- November 23: Margaret of York was fatally poisoned by the Assassins on behalf of King Richard VII of England, for plotting to claim the English throne in a Yorkist Templar plot.
- December: Cesare Borgia was arrested by Fabio Orsini on orders of Pope Julius II, after losing a fight with the Assassins in front of the Porta Aurelia in Rome.
- Cesare Borgia escaped imprisonment from the Castel Sant'Angelo, but was captured by Ezio Auditore da Firenze near Ostia. Pope Julius II struck a deal with King Ferdinand and Queen Isabela of Spain to have Cesare imprisoned in the Castillo de la Mota in Valencia.
- Claudia Auditore da Firenze stepped down as the madam of the Rosa in Fiore in Rome after having been taken captive by Templar spies. The Venetian thief Rosa took over the position.
- November 26: Queen Isabella I of Castille passed away afer having been poisoned by her servant, an acquaintance of Luis de Santángel, at the request of the Assassins for colluding with the Borgia.
- Micheletto Corella was taken captive in Zagarolo after Ezio Auditore da Firenze led a force of 100 Assassins and thieves on against Micheletto's army. Micheletto was imprisoned in the Palazzo della Signoria in Florence and interrogated.
- Ezio Auditore da Firenze locked his Apple of Eden in the First Civilization vault beneath the Colosseum, on the artifact's instructions.
- June 24: Ezio Auditore da Firenze, Niccolò Machiavelli and Leonardo da Vinci started their journey to Valencia to find Micheletto Corella, based on information from a courtesan named Camilla in Naples.
- March 12: Cesare Borgia fell to his death from the walls of Viana Castle after being dropped by the Assassin Ezio Auditore da Firenze during the Siege of Viana.
- May 14: The Republic of Venice and Kingdom of France fought at the Battle of Agnadello, resulting in a French victory. Bartolomeo d'Alviano was captured by the French, while trying to protect the Shroud of Eden from falling into King Louis XII's hands.
- September 10: An earthquake struck Constantinople. Templars fighting under the Byzantine banner re-emerged in the city.
- January: Niccolò di Pitigliano was killed by the Assassin Francesco Vecellio in Lonigo, for terrorizing the citizens of Lonigo and abandoning Bartolomeo d'Alviano at the Battle of Agnadello; Francesco took the Shroud of Eden, which Niccolò had stolen, back to the Assassins.
- May 12–30: The Prince of Anhua rebellion, orchestrated by the Chinese Assassins in an attempt to assassinate Liu Jin, leader of the Eight Tigers, took place.
- Winter: The Assassin Ezio Auditore da Firenze left Italy and started his journey to Masyaf, after having found a letter in 1509 written by his father detailing Altaïr Ibn-La'Ahad's library.
- Ezio Auditore da Firenze was captured and ambushed by Byzantine Templars under the command of Leandros in Masyaf, but escaped his execution by hanging.
- Ezio Auditore da Firenze killed Leandros in Atlas Village, after pursuing him through the Syrian countryside; Ezio retrieved The Secret Crusade by Niccolò Polo from Leandros.
- May: Ezio Auditore da Firenze arrived in Constantinople and became familiarized with the Ottoman Assassins, led by Yusuf Tazim, and their struggle against the Byzantine Templars.
- Ezio Auditore da Firenze found four of the five Masyaf Keys over the course of various months with aid from bookkeeper Sofia Sartor in the Yerebatan Cistern, the Galata Tower, the Forum of the Ox and the Maiden's Tower.
- Prince Suleiman was rescued from abduction by the Byzantine Templars at a party in Topkapı Palace by the Ottoman Assassins. Suleiman and Ezio Auditore da Firenze formed an alliance.
- The Janissary captain Tarik Barleti was assassinated by Ezio Auditore da Firenze on incorrect suspicions of colluding with the Templars.
- The Great Chain was destroyed by Ezio Auditore da Firenze with explosives. Ezio proceeded to set the docked Ottoman fleet ablaze using Greek Fire, and made his way to the Templars' hideout in Cappadocia alongside Piri Reis.
- Shahkulu, a Turkmen Templar, was killed by Ezio Auditore da Firenze in Derinkuyu with aid from the Ottoman spy Dilara.
- Ezio Auditore da Firenze destroyed the Byzantine Templars' ammunition storage inside Derinkuyu, causing the city to be filled with smoke, creating widespread panick.
- Manuel Palaiologos was killed by Ezio Auditore da Firenze in the outskirts of Derinkuyu. Ezio was confronted by Prince Ahmet, who revealed himself to be a Templar, and Ezio escaped Derinkuyu and made his way back to Constantinople.
- The Ottoman Assassin leader Yusuf Tazim was killed by the Byzantine Templars while trying to prevent Sofia Sartor's abduction in her bookshop.
- The Ottoman Assassins, led by Ezio Auditore da Firenze, besieged the Templars' hideout at the Harbor of Theodosius. Ezio was forced to spare Prince Ahmet to save Sofia Sartor's life.
- Ezio Auditore da Firenze and Prince Ahmet met on the wall connected to Galata Tower, where Ezio handed Ahmet the keys. Ahmet tricked Ezio and ordered Sofia's execution, though Ezio saved her from strangulation.
- April 25:
- May: Ezio Auditore da Firenze unlocked the library of Altaïr Ibn-La'Ahad in Masyaf, though he decided to leave the Apple of Eden locked away. Alongside Desmond Miles, in 2012, Ezio witnessed a Precursor message about the Toba catastrophe.
- June: Sofia Sartor sold her bookshop to the Ottoman Assassins, who hid the Masyaf Keys in the cistern beneath the bookshop. Ezio Auditore da Firenze became engaged to Sofia, and left for Italy.
- February: Ezio Auditore da Firenze retired as Mentor of the Italian Brotherhood of Assassins, and announced his favored successor to be Lodovico Ariosto.
- February: Hernán Cortés and an army of Spanish soldiers – including the Assassin Giovanni Borgia, posing as "Botello", on a quest to find a Piece of Eden – landed on the Yucatán Peninsula to explore Mexico.
- May 2: Leonardo da Vinci passed away in the Clos Lucé in Amboise, France, with his friend Ezio Auditore da Firenze and Niccolò Machiavelli at his side; King Francis I of France would spread stories about being at Leonardo's deathbed as propaganda.
- November 8: The Spanish expedition party led by Hernán Cortés was welcomed into Tenochtitlan by the Aztec ruler, Moctezuma II.
- May 20: The Aztecs in Tenochtitlan were massacred by the Spanish during the Toxcatl feast, in response to the gruesomeness of the feast and to plunder Aztec riches. In the chaos, Giovanni Borgia stole a Crystal Skull from an Aztec priest.
- June 29: Moctezuma II, used as a puppet by the Spanish to calm the Aztec people, was killed after one of his subjects struck his head with a stone.
- June 30: Hernán Cortés and his Spanish soldiers made a narrow escape from Tenochtitlan during the night, known as the Night of Sorrow, during which many Spanish soldiers were slaughtered by the pursuing Aztecs.
- April 20: The Zhengde Emperor of China died without an heir, leaving the country in a state of chaos. The Chinese Assassins took the opportunity to infiltrate the imperial palace and rescued several of the Emperor's concubines, including Shao Jun.
- May 27: Zhu Houcong became the Jiajing Emperor, with aid from the Templars, succeeding his cousin, the Zhengde Emperor.
- July: The Spanish conquistador Juan Ponce de León died in Havana, Cuba, after having been shot with a poisoned arrow by the Assassins in Florida for failing to heed Miguel Ramon Carlo de Lugo's warning to give up his search for the Fountain of Youth.
- August: The Jiajing Emperor of China ordered a purge of his enemies, under the influence of the Eight Tigers, a group of Templar eunuchs. This resulted in the near eradication of the Chinese Assassin Brotherhood, and the survivors fled to other countries in the west.
- November: Shao Jun met Ezio Auditore da Firenze in his villa in Tuscany. Ezio agreed to teach her how to rebuild the Order, and the two of them fought off Chinese imperial guards in Florence and Ezio's villa. Ezio entrusted Jun with the Precursor box before her departure.
- November 30: Ezio Auditore da Firenze died in Florence, as a result of the battle wounds he received during his career as an Assassin, while visiting the city with his wife Sofia and daughter Flavia.
- The Assassin Shao Jun returned to China at the request of Wang Yangming, the new leader of the Chinese Assassins, to rebuild their Brotherhood and kill the Eight Tigers.
- Shao Jun allowed herself and the Precursor box to be captured by the Eight Tigers. Jun escaped imprisonment and killed Gao Feng, while Wang Yangming killed Ma Yongcheng.
- Yu Dayong, a member of the Eight Tigers, was killed by the Assassin Shao Jun in the port city of Macau. In retaliation for the attack, Qiu Ju ordered the port set ablaze.
- Giovanni Borgia discovered the formulae for the philosopher's stone from the "True Magic" chapter of the Book of Abraham in the study of the Swiss scientist Bombastus, when Giovanni took his Crystal Skull to Bombastus for study.
- January 9:
- Qiu Ju, a member of the Eight Tigers, was killed in a duel by the Assassin Shao Jun in the Forbidden City.
- Altan Khan, ruler of the Tümed Mongols, launched an siege on the Great Wall of China. The Assassin Shao Jun thwarted the invasion by closing the wall's gates and killed the Templar Zhang Yong.
- June 26: The Spanish conquistador Francisco Pizarro, conqueror of the Inca Empire, was killed by the Assassins.
- The Assassin Giovanni Borgia communicated with the Jiajing Emperor through his Crystal Skull. Upon realizing the Emperor's threats, Borgia warned the Brotherhood of the danger.
- July 27: Francis Xavier, a Jesuit missionary, arrived in Japan to spread the influence of Christianity and the Templar Order.
- April 27: The Republic of Florence conquered Monteriggioni, after the Florentine exile Giovannino Zeti handed the town keys to Florence. The Medici allowed the Auditore to continue their rule of the town.
- November 17: Queen Mary I of England was killed by the Assassins, to free the people of England from her oppression.
- January 15: Queen Elizabeth I of England, successor to her half-sister Mary I, was crowned at Westminster Abbey and began her rule over England, aided by an Apple of Eden.
- January 23: The Jiajing Emperor, a Templar puppet, was killed by the Chinese Assassins on orders of the Mentor Shao Jun.
- July 6: Mōri Motonari, head of the Mōri clan, was assassinated by the Assassin Hattori Hanzō to allow Oda Nobunaga to conquer Chūgoku, paving the way for Tokugawa Ieyasu.
- May 13: Takeda Shingen, head of the Takeda clan, was killed in his camp during an attack by Honda Tadakatsu and the Assassin Hattori Hanzō, to obtain Shingen's Sword of Eden.
- June 21: The Battle of Gogunda was fought between the Army of the Mughal Empire and the Rajput chief Maharana Pratap Singh. Despite the Mughal Army's victory, Pratap Singh refused to recognize Mughal rule for several years until his army was defeated.
- April 19: Uesugi Kenshin, head of the Uesugi clan and a Templar, was killed by the Assassin Hattori Hanzō.
- The Jesuit missionary Francisco Cabral was forced to resign from his post by fellow missionary Alessandro Valignano, after Cabral confronted Valignano about the latter using his position to scour Japan for Templar recruits.
- November 19: Tsarevich Ivan Ivanovich of Russia, son of Ivan the Terrible, died; the Assassins were somehow involved in his death.
- June 21: Oda Nobunaga, head of the Oda clan, was attacked by his vassal Akechi Mitsuhide at Honnō-ji; he was subsequently assassinated the Assassin and monk Yamauchi Taka to obtain his Sword of Eden, which was then transported to China by Liu Yan.
- October 26: English alchemist Edward Kelley moved with his family to Třeboň from Prague, where he worked with John Dee for Count Vilem Rožmberk; using a Crystal Ball, Kelley communicated with the First Civilization.
- May: John Dee left Třeboň and returned to England after an argument with Edward Kelley over the use of the Book of Abraham; Kelley started working at the court of Holy Roman Emperor Rudolf II.
- August 18: The Roanoke Colony in the New World was found deserted; the disappearance of the colony had some relation to the Assassin–Templar War.
- The Golem killed various members of the nobility and alchemists in Prague, the seat of the Holy Roman Empire; by conversing with it, Elizabeth Jane Weston prevented its attempt to kill her stepfather Edward Kelley.
- December 23: The Assassin Hattori Hanzō was killed by his longtime rival and fellow ninja, Fūma Kotarō, in Edo.
- November 1: Edward Kelley committed suicide, by jumping off the roof of Hněvín Castle, where he was imprisoned by Emperor Rudolf II of the Holy Roman Empire, for failing to create gold.
- September 18: Toyotomi Hideyoshi, the unifier of Japan, was killed by the Assassin Yamauchi Taka in Fushimi Castle.
- October 21: The Battle of Sekigahara was fought between the forces of Tokugawa Ieyasu and Ishida Mitsunari, ending in a Tokugawa victory. Ishida's vassal Shima Sakon was assassinated by Yamauchi Taka.
- September 3: The Battle of Worcester was fought between the English Royalists and Parliamentarians, resulting in a victory for Parliament and the end of the English Civil War. Prince Charles II fled England and lived in exile in mainland Europe.
- May 29: Prince Charles II returned to London after years of exile in France, the United Provinces and Spanish Netherlands.
- May 29: King Charles II of England, Scotland and Ireland was crowned at Westminster Abbey; a man wielding a Piece of Eden was present at the coronation.
- September 2: The Great Fire of London started, destroying thousands of buildings in the medieval City of London, ending on September 5.
- April: Thom Kavanagh, a Sage from Boston, was captured by the Mentor of the Caribbean Assassins, Bahlam, to prevent him from falling under Laureano de Torres y Ayala's Templar influence.
- Louis-Joseph d'Albert de Luynes and three other Assassins attempted to recruit Julie d'Aubigny, but d'Aubigny attacked and defeated them. After a second attempt, she agreed to join the Brotherhood and started training under Maréchal.
- British pirate William Kidd hid his treasures in the New World – including his sawtooth cutlass on Cerros and his Shard of Eden on Oak Island – after realizing he was pursued by the British authorities and the Templars.
- May 23: The British privateer William Kidd was hanged in London on accussations of piracy, after having been captured in New York.
- July 9: The War of the Spanish Succession started between the powers of Europe to determine the successor to King Charles II of Spain.
- April 11: The Treaty of Utrecht was signed between the belligerents of the War of the Spanish Succession, effectively ending all armed conflict between the powers of Europe. Privateers in the West Indies were no longer needed, causing many privateers to turn to piracy.
- June: The Assassin Duncan Walpole was killed by the pirate Edward Kenway, after Walpole had killed Edward's captain Abel Bramah and both ships had been destroyed near Cape Bonavista. Stealing Walpole's identity, Edward saved Stede Bonnet from British soldiers and left with him for Havana.
- Woodes Rogers, Julien du Casse and Edward Kenway, posing as the Assassin Duncan Walpole, were inducted into the Templar Order by Grand Master Laureano de Torres y Ayala.
- The Templars killed several Assassins in Havana while protecting the Sage Bartholomew Roberts from falling into their hands. That evening, Edward Kenway was caught on suspicions of freeing the Sage, and was to be sent to the British Templars with the Spanish Treasure Fleet.
- July 30: The Treasure Fleet lost eleven of its twelve vessels in a hurricane off the coast of Florida. The remaining ship, later rechristened Jackdaw, was stolen by pirate captives led by Edward Kenway and Adéwalé, and managed to escape the storm.
- September: Julien du Casse was killed by the pirate Edward Kenway in du Casse's stronghold in Great Inagua, out of fear that du Casse had recognized the Jackdaw while sailing.
- June: The French pirate Olivier "La Buse" Levasseur destroyed a vessel captained by Barnes off Devil's Rock, and rescued its captives Alonzo Batilla and Jumao, whom he rewarded with their own ship. Alonzo subsequently obtained the schooner Wanderer.
- July: Samuel Bellamy replaced Benjamin Hornigold as captain of Hornigold's pirate fleet by majority vote and Hornigold's rule to not attack British ships was neglected. Hornigold was escorted away from the pirates to another island by Alonzo Batilla.
- November: Samuel Bellamy, La Buse and Alonzo Batilla attacked a galleon of the Spanish Treasure Fleet, but were lured into a trap by Captain Francis Hume of the British Navy, a Templar.
- Alonzo Batilla recovered Laurens Prins' slaver route and destroyed Francis Hume's ship, who had attacked Samuel Bellamy on orders of Laureano de Torres y Ayala.
- Edward Kenway attacked the fort at Punta Guarico to steal Laureano de Torres y Ayala's gold, but instead devised a plan to use Torres and his gold to acquire Bartholomew Roberts from Laurens Prins, who had the Sage in his employ.
- February: Samuel Bellamy, La Buse and Alonzo Batilla set a trap for the Whydah, Laurens Prins' slave ship transporting a Piece of Eden. The Whydah and its treasure were secured, and the pirates were able to sink the attacking King George captained by Francis Hume.
- April 27: Laurens Prins was assassinated in Kingston by Edward Kenway, aiding his friend Mary Read in finishing her assassination contract after Prins refused to sell Bartholomew Roberts. Roberts managed to escape Kingston.
- May: Alonzo Batilla aided Christopher Condent in finding supplies and rum for the Pirate Republic of Nassau; La Buse fled Nassau with the Piece of Eden after discovering the Templars had infiltrated the republic.
- September: La Buse escaped from a Templar attack on an enemy ship, leaving the wreckage of his vessel Le Postillon behind; Alonzo retrieved La Buse's codebook from the Templar merchant Barnes, detailing his location to be Mayaguana.
- December: Barnes was fatally shot by fellow Templar Christopher Condent, after being unable to discern the location of Olivier Levasseur to Condent and Benjamin Hornigold.
- January: The pirates Edward Kenway and Edward Thatch, commonly known as Blackbeard, traveled to a shipwreck of the Spanish Treasure Fleet to find medicine for the people of Nassau, without success.
- April: Edward Thatch was overrun by a British Man O' War. After being saved by Edward Kenway, Thatch's men discovered a shipment of medicine from Charles-Towne aboard the Man O' War.
- May: Edward Thatch laid siege to Charles-Towne, South Carolina for a week, holding men hostage in exchange for medicine. Edward Kenway infiltrated the town, stealing the town's medicine instead.
- July 22:
- Governor Woodes Rogers of the Bahamas arrived in Nassau with Commodore Peter Chamberlaine, extending a pardon from King George I of the Great Britain to all pirates.
- Commodore Peter Chamberlaine was assassinated by the pirate Edward Kenway for threatening the Pirate Republic. Kenway and Charles Vane destroyed the British's blockade of the city with a fireship.
- November 22: Edward Thatch was killed off the coast of Ocracoke, during a British Navy assault led by Robert Maynard. Edward Kenway and the Jackdaw managed to escape.
- November 23: Charles Vane and Edward Kenway were marooned on Isla Providencia, after Jack Rackham deposed Vane as captain and captured the Jackdaw.
- February: Edward Kenway was saved from Isla Providencia by an arriving ship, after having fought Charles Vane, who had lost his sanity on the island.
- May: The pirate Benjamin Hornigold joined the Templar Order in Kingston after accepting Governor Woodes Rogers' pardon. Edward Kenway sailed to Príncipe to save the Sage from the Templars.
- June 19: The pirate hunters John Cockram and Josiah Burgess were killed by Edward Kenway, after Kenway had saved Bartholomew Roberts from the Templars' attack. Roberts was elected as the replacement of pirate captain Howell Davis.
- Edward Kenway and Bartholomew Roberts captured the Portuguese ship Nosso Senhor da Compreensão and secured the Templars' blood vials on board. Roberts renamed the ship Royal Fortune and made it his flagship.
- Benjamin Hornigold was killed by his former friend Edward Kenway on Santanillas for betraying the Pirate Republic.
- Edward Kenway was betrayed by Bartholomew Roberts and turned in to the British authorities in Kingston, after Kenway and Roberts visited the Observatory; there, Roberts took possession of the complex' Crystal Skull.
- November 28: Mary Read and Anne Bonny were led to trial in Port Royal in Kingston, but managed to evade death by hanging by revealing their pregnancies.
- April: Edward Kenway and Anne Bonny escaped imprisonment in Port Royal, Jamaica, with the aid of the Mentor Ah Tabai; Mary Read died in prison, due to complications from childbirth. Kenway decided to join the Assassins, out of respect for Read.
- May: Governor Woodes Rogers of the Bahamas was severely wounded by the pirate Edward Kenway during a party in Kingston. Rogers survived his wounds, and later returned to England.
- November 28: The French bandit Cartouche was saved from death by his lover Mireille, the leader of the French Assassins, who managed to fake his execution. Cartouche joined the Assassin Brotherhood.
- February 10: Bartholomew Roberts was killed by the pirate Edward Kenway near Príncipe on orders of Ah Tabai, taking possession of the Crystal Skull and the blood vials. Upon Roberts' request, Edward destroyed his body to prevent it from falling into Templar hands.
- El Tiburón, Laureano de Torres y Ayala's right hand man, was killed by the pirate Edward Kenway in Castillo de San Salvador de la Punta in Havana.
- September 1: Laureano de Torres y Ayala, Grand Master of the Caribbean Templars, was killed inside the Observatory in Jamaica by the pirate Edward Kenway on orders of Ah Tabai.
- October: Edward Kenway returned to England with his daughter Jennifer Scott, who had just arrived in Great Inagua, after Kenway heard news that his wife Caroline Scott had died two years earlier.
- Edward Kenway killed the Templars Emmett Scott, father of Caroline Scott, and Wilson in a warehouse in Bristol for the pain they caused his wife and parents.
- Robert Walpole, the future Prime Minister of Great Britain, pardoned Edward Kenway and his pirate crew. Walpole purchased a house in London for Kenway, introduced him to the Stephensen-Oakley family and employed his new assistant, Reginald Birch.
- The Victoire, captained by Adéwalé, ambushed a convoy of French Templar ships near Saint-Domingue, and intercepted a parcel adressed to Bastienne Josèphe in Port-au-Prince. While fleeing from the Templars, the Victoire was destroyed in a storm, and Adéwalé washed up in Port-au-Prince.
- Adéwalé formed an alliance with Bastienne Josèphe and Augustin Dieufort, leader of the Maroon rebellion against the Governor Pierre, Marquis de Fayet. Adéwalé stole the Experto Crede and made it his flagship, and helped free the colony's slaves.
- The Experto Crede protected the Vautour, a French merchant ship transporting French scientists for the French Geodesic Mission and slave spying for the Assassins and Maroons, from pirate ships.
- December 3: The Assassin Edward Kenway was killed in his family's house in London by masked men employed by Reginald Birch, Kenway's property manager and a Templar. The masked men proceeded to steal Kenway's journal, and kidnapped his daughter Jennifer.
- December 12: Haytham Kenway, son of Edward Kenway, started his tutelage under Reginald Birch on his mother Tessa's request, and left with Birch for Europe to find Jennifer.
- On orders of Governor Pierre, Marquis de Fayet, a French vessel took down a slave ship while the Experto Crede was trying to free its slaves from the French.
- July 8: Pierre, Marquis de Fayet, Governor-General of Saint-Domingue was killed by the Assassin Adéwalé in Port-au-Prince for his harsh treatment of slaves in the colony.
- February 20: The Swedish Levant Company was founded in Stockholm, as a front for the Swedish Brotherhood of Assassins.
- April 19: Haytham Kenway was formally inducted into the Templar Order. His first mission was to kill a greedy merchant in Liverpool.
- May 11: The Siege of Louisbourg started. The Assassin John de la Tour sacrificed himself fighting off the invading British forces, while Achilles Davenport and Abigail sought the safehouse of the Hermeticist Nicolas Court.
- Achilles Davenport, a former student of the Mentor Ah Tabai in the Caribbean, established the Colonial Brotherhood of Assassins in the Thirteen Colonies and assumed the title of Mentor.
- June 11: Juan Vedomir, a Templar assigned to decode Edward Kenway's journal, was killed by Haytham Kenway for working with the Assassins. Haytham took the journal with him, and later brought it to Reginald Birch in the Templar headquarters in Prague.
- June 19: Nāder Shāh, the ruler of Iran and owner of the Koh-i-Noor, was killed by a group of assassins led by the Assassin Salah Bey. The Koh-i-Noor fell into the hands of Ahmad Shāh Durrānī.
- The brig Aquila was constructed in Brest, France on orders of the Assassin Council in Paris. The ship would become the flagship of the Assassin Navy within several years.
- November 21: The Assassin Vendredi discovered and disturbed the Piece of Eden in the First Civilization Temple near Port-au-Prince, on orders of François Mackandal, triggering an earthquake that destroyed the city. Vendredi was killed by the Templar Lawrence Washington during his escape.
- November: Master Templar Lawrence Washington stole the Precursor box and manuscript from the camp of François Mackandal in Haiti.
- January: The Assassins Liam O'Brien and Shay Cormac rescued a group of allied smugglers from the Royal Navy with the aid of the Chevalier de la Vérendrye. Shay stole the Royal Navy's sloop Morrigan.
- March: The Assassin Adéwalé met the Mentor Achilles Davenport of the Colonial Brotherhood at the Davenport Homestead to inform him that the Precursor box and manuscript had been shipped to North America. Adéwalé returned to Haiti with supplies to help victims of the earthquake.
- April: After meeting with their associate Le Chasseur, the Assassins discovered that the Precursor manuscript was in the possession of Lawrence Washington.
- July: Master Templar Lawrence Washington was killed by the Assassin Shay Cormac outside Washington's estate in Mount Vernon.
- June 25: Haytham Kenway abducted Lucio Albertine to help his mother, the captive Monica Albertine, a codebreaker and Assassin associate, decode Edward Kenway's journal for the Templars. Haytham stole the Hidden Blades of Miko, Lucio's Assassin bodyguard, while engaged in combat with him.
- April 18: Haytham Kenway assassinated Miko during a performance of The Beggar's Opera at the Theatre Royal in London, and retrieved the Grand Temple's key.
- April 20: Haytham Kenway boarded the Providence to start his 72-day long journey to the New World to find the Grand Temple. During the journey, Haytham killed the Assassin sailor Louis Mills and managed to evade capture by the Aquila, luring it to destruction in the storm.
- May: The Templar Samuel Smith was killed by the Assassins Shay Cormac in Terra Nova. Cormac retrieved the Precursor box from Smith.
- The Templar James Wardrop was assassinated by the Assassin Shay Cormac during the Albany Congress in Albany, New York. Cormac retrieved the Precursor manuscript from Wardrop.
- Benjamin Franklin, with the use use of electricity and help of the Assassins Shay Cormac and Hope Jensen, made the Precursor box functional. Reading the manuscript, the box displayed a holographic map of the globe, highlighting Port-au-Prince, Lisbon and the Arctic.
- July 8: Haytham Kenway arrived in Boston, Massachusetts and formally took up the position of Grand Master of the Colonial Templars, recruiting Charles Lee, William Johnson and Thomas Hickey.
- July 10: Haytham Kenway and Charles Lee rescued the surgeon Benjamin Church from capture by the slaver Silas Thatcher, and recruited him into the Colonial Templars.
- July 13: Haytham Kenway recruited the soldier John Pitcairn into the Colonial Templars, after attacking and threatening his former comrade Edward Braddock.
- July 14: The Colonial Templars besieged the fortress of Southgate in Boston, killing the slaver Silas Thatcher in the process.
- November 15: Haytham Kenway formed an alliance with Kaniehtí:io, a Kanien'kehá:ka woman who could lead him to the Grand Temple, by planning a joint attack on Edward Braddock.
- July 9: General Edward Braddock was fatally wounded by Haytham Kenway during the Braddock Expedition, with aid from Kenway's fellow Templars, Kaniehtí:io, the Abenaki, Shawnee and Lenape, for his betrayal of the Templar Order's principles. Braddock died four days later.
- November 1: The Assassin Shay Cormac disturbed the Piece of Eden in the Temple beneath the Carmo Convent in Lisbon, causing an earthquake that destroyed the city and killed thousands of citizens.
- The Assassin Shay Cormac stole the Precursor manuscript from the Davenport Homestead, believing that Achilles knew about the Seismic Temples, but was attacked by the Mentor. Cormac jumped off a cliff in the Homestead after having been cornered by the Assassins.
- Shay Cormac was nursed back to health by Barry and Cassidy Finnegan at the request of Colonel George Monro, a Templar. On the insistence of Monro, Cormac started financing the renovations of New York.
- Shay Cormac rescued Christopher Gist from hanging by the Assassin-affiliated gangs in New York, from whom he reclaimed the Morrigan, and seized Fort Arsenal as his new home.
- Le Chasseur, a smuggler and ally of the Assassin Order, was killed during a Templar attack on Fort La Croix by Shay Cormac.
- May 1: Jeanne fled from New Orleans to a working colony in Chichen Itza, Mexico with the aid of her former husband Philippe Olivier de Grandpré's new wife Madeleine de L'Isle, leaving her daughter Aveline de Grandpré in the care of Madeleine.
- August 10: Colonel George Monro escaped an Abenaki ambush led by the Assassin Kesegowaase with the aid of Shay Cormac, after being released following his surrender at the Siege of Fort William Henry.
- September 17: Jennifer Scott was rescued by Haytham Kenway and Jim Holden from servitude at the palace of Governor As'ad Pasha al-Azm of Damascus, after having spent years as a concubine at Topkapı Palace.
- October 9: Grand Master Reginald Birch was killed in his chateau near Troyes, France by Jennifer Scott, with the help of her brother Haytham Kenway, for having been responsible for their father's death and selling her into slavery.
- November 3: The Assassin Kesegowaase was killed by Shay Cormac. The Templar George Monro was killed in a fire lit by the Assassin Liam O'Brien.
- January 20: François Mackandal, Mentor of the Assassin Brotherhood in Saint-Domingue, was publicly executed after attempting to poison the white inhabitants of the colony. His pupils Agaté and Baptiste fled to Louisiana.
- June 8–July 26: The Siege of Louisbourg was fought between the Royal Navy and French Navy. The Templars, using James Cook's HMS Pembroke, thwarted an attack by the Experto Crede captained by the Assassin Adéwalé during the attack.
- The Assassin Adéwalé was killed by Shay Cormac at Vieille Carrière during a confrontation between the Assassin, Cormac and Grand Master Haytham Kenway.
- October: The Assassin Hope Jensen was killed by Shay Cormac following an altercation inside her mansion in New York. The Assassin Liam O'Brien returned to Achilles Davenport with the location of another temple retrieved from the Precursor box.
- November 12: Aveline de Grandpré was recruited into the Assassin Brotherhood by the Mentor Agaté. After several months of training, she was formally inducted into the Order.
- The Chevalier de la Vérendrye, an Assassin, was killed by the Templar Shay Cormac in the North Atlantic during an expedition to distract the Templars from their search for the Precursor temple in the Arctic.
- March: A First Civilization temple in the North Atlantic created an earthquake after its Piece of Eden was disturbed during a confrontation between Achilles Davenport, Liam O'Brien, Haytham Kenway and Shay Cormac. Liam was killed by Shay, and Achilles was shot in the leg by Haytham.
- November 2: The Kanien'kehá:ka village of Kanatahséton was set aflame by George Washington of the British Army, killing many villagers including Kaniehtí:io, after her son Ratonhnhaké:ton was attacked by the Colonial Templars led by Charles Lee.
- The Colonial Templars effectively destroyed the Colonial Brotherhood by wiping out nearly all of its remaining members. Achilles Davenport entered a life of exile in the Davenport Homestead.
- February 4: Jean-Jacques Blaise d'Abbadie, the Governor of Louisiana, was assassinated by the Assassin Aveline de Grandpré for colluding with the Templar Order to hand over the colony to Templars in the Spanish government.
- June 23: Baptiste, the leader of a Maroon smuggling operation impersonating his former Mentor François Mackandal, was killed by the Assassin Aveline de Grandpré for colluding with the Templar Order, on orders of Baptiste's former Brother, Agaté.
- October 27: Antonio de Ulloa, the Spanish Governor of Louisiana, was attacked by the Assassin Aveline de Grandpré while trying to escape New Orleans during the Louisiana Rebellion. Aveline spared the Governor's life and retrieved a map leading to a Templar work camp in Chichen Itza.
- Aveline de Grandpré killed the Templar Rafael Joaquín de Ferrer in First Civilization ruins underneath Chichen Itza, where the Templars had set up a working colony. Aveline also obtained half of a Prophecy Disk, and was reunited with her mother Jeanne.
- October 4: Ratonhnhaké:ton, son of Haytham Kenway and Kaniehtí:io, came into contact with Juno through the Clan Mother's Crystal Ball, who informed him that he needed to join the Assassin Order in order to protect his village from destruction.
- October 29: Achilles Davenport, former Mentor of the Colonial Assassins, took Ratonhnhaké:ton under his tutelage after seeing him defend himself against a group of attackers.
- March 5: The Boston Massacre occurred, causing British colonists to attack British Army soldiers, after Charles Lee ignited the crowd by firing a shot on orders of Haytham Kenway. Ratonhnhaké:ton, who was blamed for the event, was able to escape with help of Samuel Adams.
- March 18: Ratonhnhaké:ton received his pair of hidden blades from Achilles Davenport, and started reconstruction on the Aquila, anchored in the harbor of the Davenport Homestead.
- The Spanish Templar Diego Vázquez's attempts to take over smuggling operations in the Louisiana Bayou were disrupted by the Assassin Aveline de Grandpré, with the aid of Agaté, Gérald Blanc, Élise Lafleur and Roussillon.
- Aveline de Grandpré returned to Chichen Itza, where she made peace with her mother Jeanne and received another half of a Prophecy Disk using a map leading to another First Civilization ruin.
- November 6: Ratonhnhaké:ton aided the Sons of Liberty in defying William Johnson's smuggling operation by destroying his shipments of tea in Boston's harbor, to disrupt William Johnson's purchase of indigenous American land.
- December 3: Stephane Chapheau killed one of William Johnson's tax collectors, with aid from Ratonhnhaké:ton, and started his tutelage under the Assassin.
- December 16: The Boston Tea Party occured, in which members of the Sons of Liberty movement and Ratonhnhaké:ton dumped British shipments of tea into Boston's harbor in defiance of British authority.
- July 11: William Johnson was killed by Ratonhnhaké:ton in front of Johnson Hall, amidst a violent business deal to purchase the lands of clans of the Iroquois Confederacy.
- April 18: Members of the Sons of Liberty rode out to warn British colonists of an imminent attack by the British Army; with aid from Ratonhnhaké:ton, Paul Revere warned their allies in Lexington and then proceeded to Concord with William Dawes, though the two men were detained by British soldiers.
- April 19: The British Army and colonial militia engaged at the Battles of Lexington and Concord, where the militia under leadership of John Parker, James Barrett and Ratonhnhaké:ton managed to emerge victorious.
- June 16: The Continental Army was formed by the Patriot colonists. The Continental Congress appointed George Washington to be its Commander-in-Chief.
- June 17: The Continental Army and British Army fought at the Battle of Bunker Hill at Charlestown, Massachusetts. British Army commander John Pitcairn was assassinated during the battle, though the British managed to claim victory and captured Charlestown.
- Eseosa, grandson of Adéwalé, began to rebuild the Assassin Brotherhood in Saint-Domingue, recruiting Dutty Boukman, Toussaint Brédá, Georges Biassou, Jean-François Papillon and Jeannot Bullet into his ranks.
- George Davidson, an African slave, joined up with a group of American revolutionaries and escaped to the Thirteen Colonies with the help of Aveline de Grandpré, on request of Madeleine de L'Isle.
- June 28: Ratonhnhaké:ton was led in New York to hang after having been imprisoned alongside the Templar Thomas Hickey while trying to prevent the latter's assassination of George Washington. With aid from Achilles Davenport and Haytham Kenway, Ratonhnhaké:ton escaped and killed Hickey.
- July 4: The Declaration of Independence was signed by the Founding Fathers, proclaiming independence of the Thirteen Colonies as the United States from Great Britain.
- September 21: The Great Fire of New York started, destroying the area west of Broadway in the city.
- October 13:
- December 25: Continental Army forces led by George Washington and accompanied by Ratonhnhaké:ton crossed the icy Delaware River to launch a surprise attack on Hessian forces at Trenton, New Jersey.
- December 27: The Assassin Charles Dorian was killed by the Templar Shay Cormac in the Palace of Versailles, after Charles was entrusted with the Precursor box at an Assassin meeting.
- George Davidson, who had become a Templar fighting in Lord Dunmore's Ethiopian Regiment, was killed by Aveline de Grandpré with aid from Ratonhnhaké:ton. From Davidson, Aveline was able to discern that the Company Man was Madeleine de L'Isle.
- Agaté committed suicide after having been bested by Aveline de Grandpré when he attacked her upon hearing news of the Company Man's identity.
- Madeleine de L'Isle was killed by Aveline de Grandpré in Saint Louis Cathedral during her feigned induction into the Templar Order. After her stepmother's death, she activated the Prophecy Disk and witnessed a recording of Eve's election to leader of the human rebellion from around 75010 BC.
- January 7: Haytham Kenway and Ratonhnhaké:ton formed an alliance to pursue Benjamin Church, who had betrayed both the Templar Order and the Continental Army, stealing several of the Army's supply crates.
- January 26: Haytham Kenway and Ratonhnhaké:ton besieged the old Smith and Company Brewery in pursuit of Benjamin Church, though instead found a decoy of Church and were attacked by his henchmen, resulting in the brewery being set aflame.
- March 7: Benjamin Church was killed by Haytham Kenway and Ratonhnhaké:ton aboard his ship off the coast of Martinique, where the pair recovered the stolen supplies of the Continental Army.
- March 17: Admiral Nicholas Biddle of the Continental Navy, a Templar, was killed by Ratonhnhaké:ton on the Caribbean Sea, by destroying Biddle's ship the Randolph.
- June 16: Haytham Kenway and Ratonhnhaké:ton attacked and captured several British soldiers in New York to discern the British Army's plans, learning that they planned to march from Philadelphia to New York.
- June 17: George Washington ordered an attack on the village of Kanatahséton after receiving reports of indigenous tribes allying with the British; Ratonhnhaké:ton managed to hold off the attack, but was forced to kill his friend Kanen'tó:kon.
- June 28: The Continental Army, led by the Marquis de Lafayette and aided by Ratonhnhaké:ton, fought the British Army at the Battle of Monmouth in an attempt to stop their march on New York.
- September 24: Major General Benedict Arnold betrayed the Continental Army with help from John André, and attempted to surrender the garrison at West Point to the British, resulting in the Battle of West Point. Ratonhnhaké:ton ensured the Patriots' victory, but Arnold escaped by boat.
- September 5: The French Navy, aided by the Aquila, defeated the British Navy at the Battle of the Chesapeake; in exchange for Ratonhnhaké:ton's aid, the French Navy shelled New York with ships for the Assassin's attack on Fort George.
- September 16: Haytham Kenway was killed by his son Ratonhnhaké:ton, who planned to eliminate Charles Lee instead, during his infiltration of Fort George, which was besieged by the French Navy.
- October 19: The Continental Army claimed victory at the Siege of Yorktown, effectively winning the American Revolutionary War; George Washington retrieved an Apple of Eden at Yorktown.
- October 2: Charles Lee was killed by Ratonhnhaké:ton in the Last Drink tavern in Monmouth, after the Assassin had pursued Lee through New York and Boston, taking the Grand Temple's key.
- April: Ratonhnhaké:ton came into contact with Juno through his village's Crystal Ball, who told him to hide the Grand Temple's key somewhere safe; the village's inhabitants had been forced to migrate as their land had been sold by the new government.
- September 3: The Treaty of Paris was signed between delegates of Great Britain and the Thirteen Colonies, formally ending the American Revolutionary War and establishing the United States.
- November 25: The last remaining troops of the British Army departed from the new free and independent State of New York in the United States on Evacuation Day.
- Doctor Edmund Judge, a Templar, was killed by the Assassin Aveline de Grandpré in Newport, Rhode Island, while trying to obtain Patience Gibbs' charm, the teenage leader of a group of escaped slaves, into the Assassin Brotherhood for Ratonhnhaké:ton.
- April 30: George Washington was inaugurated as the first President of the United States at Federal Hall in New York, after a short retirement at Mount Vernon.
- May 5:
- The Estates-General gathered in Versailles, where King Louis XVI of France discussed France's economic crisis.
- François de la Serre, Grand Master of the French Templars, was killed by Charles Gabriel Sivert and Le Roi des Thunes in a Templar coup d'état orchestrated by François-Thomas Germain. De la Serre's adoptive son Arno Dorian was arrested for the murder.
- July 14: The Bastille in Paris was stormed and captured by the Parisian militia, signalling the start of the French Revolution. The Assassin Pierre Bellec and Arno Dorian escaped captivity in the Bastille.
- October 5–6: The Women's March on Versailles occurred in protest against the monarchy of France. A team of Assassins, including Arno Dorian, ensured the march remained peaceful.
- January 5: Charles Gabriel Sivert, baron de l'Espérance, a Templar, was killed by the Assassin Arno Dorian in the Notre-Dame in Paris.
- January 19: Le Roi des Thunes, the leader of the Cour des Miracles and a Templar, was killed by the Assassin Arno Dorian. The Marquis de Sade became the new leader of the Cour.
- March 31:
- Arno Dorian rescued François-Thomas Germain, secretly the new Templar Grand Master, after he feigned capture by the Templars inside his silversmith workshop. Germain falsely accused Chrétien Lafrenière of having commissioned the pin that killed François de la Serre.
- The Templar Chrétien Lafrenière was killed by Arno Dorian during a meeting between his faction of conservative French Templars and members from other European branches.
- April 2: Honoré Gabriel Riqueti, comte de Mirabeau, Mentor of the French Assassins, was poisoned by fellow Assassin Pierre Bellec because of his willingness to work with the Templars. Bellec attempted to frame the Templar Élise de la Serre for the murder.
- August 14: Dutty Boukman held a religious ceremony at Bois Caïman, prophesizing that Jean-François Papillon, Georges Biassou and Jeannot Bullet would become leaders of a revolution to free the slaves of Saint-Domingue.
- August 21: The Haitian Revolution ignited; led by members of the Assassin Brotherhood, the slaves of Saint-Domingue rose up in revolt against their French masters.
- November: Dutty Boukman was killed in battle with the French Army near Acul. Jeannot Bullet was ordered to death by Eseosa for breaking the tenets of the Creed.
- August 10: Tuileries Palace, the residence of King Louis XVI, was stormed by an armed mob. The Assassin Arno Dorian retrieved the King's correspondence with his late Mentor Mirabeau and Napoleon retrieved a First Civilization temple key from the King's secret hiding place.
- September 2: A team of Assassins, including Arno Dorian, aided Georges Danton's attempt to stop an Austrian spy ring by killing the Comte and Vicomte de Gambais.
- January 21: King Louis XVI of France was executed by guillotine in Paris, as decreed by the National Assembly with the Templars' influence. Arno Dorian and Élise de la Serre made a failed assassination attempt on Grand Master François-Thomas Germain.
- August 29: The French civil commissioner of Saint-Domingue, Léger-Félicité Sonthonax, declared all slaves in the colony to be freed men.
- July 28:
- Maximilien de Robespierre, a French politician and Templar, was executed by guillotine in the Place de la Révolution.
- François-Thomas Germain, Grand Master of the French Templars, was killed by Arno Dorian in the Templar crypt beneath the Temple in Paris. Before his death, Germain killed Élise de la Serre using the Sword of Eden.
- August 9:
- Arno Dorian entered the Saint-Denis Temple, where he killed Philippe Rose and retrieved the Head of Saint-Denis. After using the Head to escape, Arno retrieved an Apple of Eden from the artifact and sent it to Al Mualim in Cairo, Egypt.
- Napoleon Bonaparte was arrested and placed under house arrest for supporting Maximilien Robespierre during the French Revolution and stealing a small army to search for an artifact in Franciade.
- August 20: Napoleon Bonaparte was released from house arrest due to his powerful influence.
- October 5: The royalist uprising of 13 Vendémiaire was suppressed by the French Republic under leadership of Paul Barras and Napoleon Bonaparte. Bonaparte earned infamy for attacking the royalists in Paris with cannons.
- August 24: Toussaint Louverture expelled Léger-Félicité Sonthonax from Saint-Domingue and became de facto ruler of the colony.
- May 19: Napoleon Bonaparte embarked from Toulon on an expedition to Egypt and Syria, secretly with intention of acquiring the artifact from the Saint-Denis Temple.
- July 15: A soldier of the French expedition in Egypt discovered the Rosetta Stone, a stele inscribed with a decree issued at Memphis. The stele was missing part of the first script pertaining to the Assassins.
- August 24: Napoleon Bonaparte set sail for France from Egypt, after having successfully retrieved the Apple of Eden of the Saint-Denis Temple.
- November 9: Napoleon Bonaparte established himself as the new ruler of France as First Consul during the coup of 18 Brumaire.
- December 24: An attempt on the life of Napoleon Bonaparte using the Machine Infernale, known as the plot of the rue Saint-Nicaise, was thwarted by a team of Assassins including Arno Dorian.
- July: Toussaint Louverture captured the Spanish colony of Santo Domingo, with aid from Eseosa, becoming the leader of Hispaniola and freeing all slaves across the island.
- May: Toussaint Louverture surrendered to General Charles Leclerc, sent by his brother-in-law Napoleon Bonaparte, who falsely claimed that France had no intention of restoring racial hierarchy in Saint-Domingue.
- November 1: Charles Leclerc died of poisoning by Eseosa, though his cause of death was believed to be yellow fever.
- November 18: Jean-Jacques Dessalines, one of Toussaint Louverture's lieutenants, defeated General Rochambeau at Vertieres. Rochambeau pulled out of Vertieres at night, knowing the colony was finally lost to France.
- January 1: Jean-Jacques Dessalines declared himself leader of the free republic of Saint-Domingue, and subsequently exterminated thousands of white people living in the country.
- March 1: Eseosa started training under Ratonhnhaké:ton at the Davenport Manor in Massachusetts in preparation for his assassination of Jean-Jacques Dessalines for his tyranny over Saint-Domingue.
- August: Napoleon Bonaparte and Arno Dorian entered the crypt beneath the Temple in Paris, and buried the remains of François-Thomas Germain in the Parisian catacombs.
- The Château Clique – leaders of the Templar Order in Lower Canada – arrested several journalists, including the Assassin Ludger Duvernay, for publishing articles accusing the Canadian administration of serving the Château Clique. Duvernay was freed by the Assassins.
- March 8: The Assassin Ludger Duvernay founded the Saint-Jean-Baptiste Society in opposition of the Château Clique.
- June 24: The first Saint-Jean-Baptiste Day was celebrated in the gardens of John McDonnell's house in Montreal, where a Templar agent killed one of McDonnell's servants.
- June 27:
- The Assassin Arbaaz Mir and Raza Soora retrieved the Koh-i-Noor from the Amritsar Temple underneath the summer palace of Ranjit Singh, after being tasked by the Mentor Hamid to protect it from the Templars.
- Maharaja Ranjit Singh of the Sikh Empire was fatally poisoned by William Hay Macnaghten and Templar General Francis Cotton to help the British Empire conquer India, though secretly under the Templar banner.
- Princess Pyara Kaur activated the Koh-i-Noor, taking the shape of a member of the First Civilization. Telling humanity to stand united, the Precursor was shot at by Francis Cotton, instead destroying the diamond. Enraged, the Precursor released a burst of energy, killing Cotton.
- March 29: The Sikh Empire fell at the end of the Second Anglo-Sikh War. Control of the region fell to the British Templars, in the name of the British Empire.
- November 19: President Abraham Lincoln of the United States delivered the Gettysburg Address in commemoration of the fallen soldiers at the Battle of Gettysburg.
- April 26: John Wilkes Booth was killed by the Assassins for the assassination of President Abraham Lincoln of the United States.
- September 2: Nikola Tesla fled to Tomingaj in Croatia to avoid being drafted into the army. While exploring the wilderness and mountains, Tesla found an Apple of Eden, which inspired him to pursue a life of study and innovation.
- March 13: Tsar Alexander II of Russia, a Templar puppet, was killed in a bomb attack by the Narodnaya Volya, the public front for the Russian Assassins.
- June 6: Nikola Tesla arrived in New York City. He started working for Thomas Edison, a Templar, but left Edison Machine Works in 1885.
- May 20: Several Assassin members of the Narodnaya Volya, including Aleksandr Ulyanov, were publicly hanged after a failed assassination attempt on Tsar Alexander III of Russia.
- Mina Bergson, a member of the Assassin Order, was tasked to infiltrate the Hermetic Order of the Golden Dawn, and eventually married Samuel Liddell MacGregor Mathers, one of its co-founders and a Templar puppet.
- October 29: The Assassin Nikolai Orelov attempted to assassinate Tsar Alexander III of Russia, a Templar ally, aboard his train bound for St. Petersburg, resulting in the Borki train disaster. The Tsar ultimately spared the Assassin's life.
- December 20: William Robert Woodman was killed by an assassin employed by his co-founders of the Hermetic Order of the Golden Dawn, Samuel Liddell MacGregor Mathers and William Wynn Westcott, after a meeting with Gustav Meyrink.
- November 1: Tsar Alexander III of Russia died of kidney failure, caused by injuries sustained by Nikolai Orelov in 1888. His son, Nicholas II, succeeded him.
- Samuel Liddell MacGregor Mathers assumed full leadership of the Hermetic Order of the Golden Dawn, after an argument between Mathers and William Wynn Westcott forced the latter to leave the Order.
- January 22: Queen Victoria of the United Kingdom passed away at the age of 81, marking the end of the Victorian era.
- December: Financier John Pierpont Morgan withdrew his funding of Nikola Tesla's experiments after Tesla intended to make electricity a free product, which stood in opposition of the Templars' plans.
- June 30: Nikola Tesla released a burst of electricity to a Templar research facility in Tunguska from his Wardenclyffe Tower during an Assassin raid on the facility, destroying the Staff of Eden that was held in the facility and creating a large eruption known as the Tunguska explosion. Nikolai Orelov was the only survivor.
- November: Frank A. Vanderlip, Paul Warburg, Charles Norton, Benjamin Strong, Jr., Henry Pomeroy Davison and Nelson W. Aldrich, members of the Templar Order, met on Jekyll Island and designed the "Plan" to take control of the capitalist market.
- Skulls of the First Civilization were found in the village of Boskop in South Africa in autumn.
- December 23: The Federal Reserve System was created as part of the "Plan" designed by the Templars, and as the first step to controlling the capitalist market.
- June 28: Archduke Franz Ferdinand of Austria was assassinated in Sarajevo by a member of the Black Hand, sparking World War I.
- June 29: Khioniya Guseva, disciple of Grigori Rasputin, attempted to kill her master in Pokrovskoye. Even though his intestines fell out, Rasputin managed to use the powers of the splinter of the Staff of Eden to survive and force Guseva to mutilate herself.
- December 24: On Christmas Eve, British and German soldiers called a truce amidst the fighting of World War I. During the truce, an Assassin operating as a medic for the British killed General Erich Albert, a Templar.
- December 29: The Templar agent Grigori Rasputin was assassinated by a group of conspirators led by Felix Yusupov, with influence of the Assassins.
- March 15: Tsar Nicholas II of Russia abdicated the Russian throne after the start of the Russian Revolution, under pressure of the Assassins.
- November 7: Nikolai Orelov infiltrated the Winter Palace in Petrograd, tasked by Vladimir Lenin to kill Tsarevich Nicholas II of Russia. After finding out that the Imperial Sceptre in the Palace was a mere replica of the Staff of Eden, Orelov decided to spare the Tsarevich's life.
- November 15: Nikolai Orelov infiltrated the asylum in Krasnoyarsk to meet Khioniya Guseva. After hearing her account of the splinter's power, he granted her wish to die by killing her with his hidden blade.
- November 22: Nikolai Orelov and two henchmen unearthed the corpse of Grigori Rasputin to recover the splinter of the Staff of Eden, based on information of Tsarevich Nicholas II.
- December: Several scientists and members of the Russian Assassin Brotherhood, including Sergei and his wife, left to form a community in an Assassin science city at a facility in Protvino, provided by the Russian Academy of Sciences.
- Nikolai Orelov, his wife Anna and daughter Nadya, fled Russia using the splinter of the Staff of Eden and settled in the United States.
- November: Moina Mathers, formerly Mina Bergson, took leadership of the Hermetic Order of the Golden Dawn and abandoned the Assassin Order after the death of her husband Samuel Liddell MacGregor Mathers.
- November 7: In twelve cities in the United States, agents of the Bureau of Investigation launched the Palmer Raids, directed by Alexander Mitchell Palmer, to arrest and deport radical leftists, though many innocents including Anna and Nadya Orelov were also rounded up.
- January: Nikolai and Innokenti Orelov were attacked by the Assassin Sergei, who was tasked to bring Nikolai back to the Russian Assassins, at their cabin in the woods of Connecticut, though Sergei was killed in the process.
- October 31: The illusionist Harry Houdini was killed by the Templars to retrieve the Piece of Eden he possessed, which he used to obtain fame during his career.
- Nikolai and Innokenti Orelov were tracked down by a team of Assassins working for the Bureau of Investigation. They took down all Assassins except the team's leader, who managed to catch Nikolai. His son complied to Nikolai's request to shoot the man, killing both the team leader and Nikolai.
- March 12: Mahatma Gandhi started the Salt March in disobedience against the British's salt laws in India until April 5, and managed to gather a large following with aid from his Apple of Eden.
- Abstergo Industries was founded by the Templar Order as a public front, which would primarily be used as a shadow company to control the world's capitalist market.
- September 1: World War II started, orchestrated by the Templar Order, employing their puppets Adolf Hitler, Joseph Stalin, Winston Churchill and Franklin D. Roosevelt to bring chaos and turmoil to the world population.
- January 7: Nikola Tesla died in a hotel room in New York City. The Templars pressured the FBI to order the Alien Property Custodian to seize Tesla's belongings.
- October 28: The USS Elridge briefly manifested in a future state using the powers of a Piece of Eden, as part of the Philadelphia Project.
- July 1–22: The Bretton Woods conference was held by European powers – secretly economic agents of the Templars – to form the World Bank, as part of the "Plan".
- December 25: An agent of Abstergo Industries purchased the Shroud of Eden from a member of the Baguttiani in Milan, Italy.
- April 30: Adolf Hitler was killed by the Assassins outside his Führerbunker, after having killed his body double inside the hideout. The Assassins also took possession of his Apple of Eden.
- July 16: The Manhattan Project tested its first atomic bomb, designed by J. Robert Oppenheimer, at the Los Alamogordo air base in New Mexico. The tests were authorized by Abstergo Industries.
- August 6–9: The first atomic bomb was dropped on Hiroshima on August 6 by the United States, and a second hit the city of Nagasaki on August 9.
- August 12: Emperor Hirohito of Japan surrendered to the Allies, marking the end of World War II.
- January 30: Mahatma Gandhi was assassinated by the Templars to retrieve his Apple of Eden, after he had used it to lead a non-violent rebellion against British rule in India.
- August 16: British economist Harry Dexter White was killed by the Templars after betraying the Order by warning the Soviet Union of their capitalist plans.
- June 17: Rocket engineer Jack Parsons died due to injuries received in an explosion in his laboratory orchestrated by Abstergo Industries, after Parsons made plans to reveal the secrets behind Aleister Crowley's formula.
- March 5: Joseph Stalin, leader of the Soviet Union, was killed by the Assassins with the use of poison, making it look like he died of a stroke.
- August 19: Prime Minister Mohammad Mosaddegh of Iran was overthrown in a coup d'état orchestrated by Abstergo Industries to stop his plans to nationalize the Iranian oil industry.
- June 7: Alan Turing was poisoned by the Templars after failing to cooperate with their orders to not build a robot, as they feared it would lead to mass unemployment and a drop in human birth rate.
- June 27: President Jacobo Árbenz of Guatemala was overthrown in a coup orchestrated by Abstergo Industries to protect their capitalist interest.
- July 29: The National Aeronautics and Space Administration (NASA), a government agency of the United States, was founded, with influence of Abstergo Industries.
- November 22: President John F. Kennedy of the United States was assassinated by the Templar sleeper agent Lee Harvey Oswald. While his driver, the Templar plant William Greer, retrieved the President's Apple of Eden, another Apple was used to create a phantom on a nearby hill to cause confusion.
- July 21: NASA's Apollo 11 spaceflight to the Moon, funded by Abstergo Industries, resulted in the recovery of an Apple of Eden from the Moon's surface.
- Abstergo Industries' first Precursor Habitation Expedition took place as the second phase of what later became the Phoenix Project. By the end of the decade, the expeditions uncovered seven large Denisovan sites across the globe.
- April 21: François Duvalier, the fortieth President of Haiti, was killed by the Assassins, for his oppression over the Haitian people.
- September 11: President Salvador Allende of Chile was overthrown and killed in a military coup orchestrated by Abstergo Industries and engineered by Henry Kissinger to stop the nationalization of industries in Chile.
- The Assassin William Miles stole the blueprints for Abstergo Industries' Animus, and gave them to a fellow member of his Order in Moscow after she rescued him from Templar agents, and told her to build it.
- Abstergo Industries started the Animus Project, directed by Dr. Warren Vidic, with the intention of exploring the genetic memories of subjects to discover the secrets of the Assassins and the Pieces of Eden.
- July 29: Abstergo Industries' Surrogate Initiative passed its twenty-third test session to relive the genetic memory of another individual, when its director Aileen Bock relived the memories of Miriam Kurtz through her son Seamus' DNA.
- August 9: Aileen Bock was severely injured in an accident involing the Animus during the thirty-seventh test session of the Surrogate Initiative, after which the project was put on halt.
- February 9: A 10-year old boy, later named Daniel Cross, was kidnapped by Abstergo Industries and used as Subject 4 of the Animus Project. During his time at Abstergo's Philadelphia facility, his memories were implanted with a hidden impulse to kill the Mentor of the Assassin Brotherhood, before being released from captivity.
- September: Warren Vidic experimented on Daniel Cross with a device capable of mimicking Piece of Eden capabilities across a network, between Subject 4's Animus sessions.
- August 19–21: President Boris Yeltsin of Russia took political power from President Mikhail Gorbachev in a staged coup d'état by standing up to communism, with aid from Abstergo Industries.
- December 8: The Belavezhskaya Accords were signed in the Belavezhskaya Forest by the Presidents of Russia, Ukraine and Belarus, declaring the dissolution of the Soviet Union.
- December 25: Mikhail Gorbachev announced his resignation as President of the Soviet Union, making Boris Yeltsin the leader of Russia.
- January: Abstergo agents buried several constructed skeletons near the site of Tim D. White's expedition in Ethiopia, to prevent knowledge of the First Civilization creating the human race becoming public.
- April 23: Daniel Cross was brought to an Assassin compound outside Philadelphia by the Assassin Hannah Mueller to meet Paul Bellamy, after noticing Daniel's Assassin tattoo and witnessing him attack a man he called a Templar as a result of the Animus' Bleeding Effect.
- April 24: Daniel Cross had a vision and discovered his purpose to find the Mentor, while reliving his ancestor Nikolai Orelov's memories of the Tunguska explosion. Daniel and Hannah visited Assassin hideouts around the globe for two years to find the Mentor.
- September 4–16: Apartment buildings in the cities Buynaksk, Moscow and Volgodonsk in Russia were bombed by Chechen terrorists, orchestrated by Abstergo Industries to boost the popularity of presidential candidate Vladimir Putin.
- May 7: Vladimir Putin became the second President of Russia, after winning the 2000 presidential election rigged by Abstergo Industries.
- November 6: The Mentor was killed by the unwitting Templar sleeper agent Daniel Cross, sending the Assassin Order into chaos and removing their influence over the 2000 American presidential election.
- November 21: Daniel Cross returned to the Abstergo Industries facility in Philadelphia. After entering the Animus, Daniel revealed the location of Assassin compounds and Abstergo initiated the Great Purge: a worldwide operation in which Abstergo strike teams attacked Assassin hideouts.
- January 20: George W. Bush became the forty-third President of the United States, after winning the 2000 presidential election rigged by Abstergo Industries.
- October 7: The War on Terror started. At some point, William Miles tasked Emmanuel Barraza with finding a Templar presence in the war, but ended up killing innocent children armed with bombs on a bus aimed for peace talks. Emmanuel vowed to never take a life again.
- October 19: Daniel Cross infiltrated the Assassins' hidden Library of Ivan the Terrible beneath the Bolshoi Theatre in Moscow, where he killed the Assassin sentry and acquired the Prophet's Codex, written by Ezio Auditore da Firenze.
- March 13: Desmond Miles ran away from "the Farm", the Assassin community in the Black Hills in South Dakota he grew up in, on his sixteenth birthday, to escape the life his parents had chosen for him.
- March 20: The Iraq War started under influence of George W. Bush as part of the War on Terror, planned by Abstergo Industries to privatize the oil market in Iraq.
- December 25: Vanessa, a scientist working at the Landing Operations Control Center of the National Space Center, sold the control codes of the Beagle 2 to Robert Getas, an employee of Abstergo Industries.
- The Assassin Lucy Stillman infiltrated Abstergo Industries after being contacted by Dr. Warren Vidic, who took an interest in her study of cognitive neuroscience. Over time, she grew to resent her old mentor William Miles, believing the tasks for the Assassins to be inhumane, and joined the Templar Order.
- Leila Marino, an employee of Abstergo Industries, allegedly committed suicide. An individual named Neumann was involved in her death, and Marino's file became classified.
- August: Clay Kaczmarek started his training to become an Assassin under William Miles.
- January: Clay Kaczmarek infiltrated the Abstergo Campus on orders of William Miles, and retrieved data related to the Animus Project.
- April 20: A large amount of oil was spilled into the Gulf of Mexico until 15 July, under contract of Abstergo-controlled British Petroleum. BP cleaned up the oil, which was worth billions of dollars.
- December 10: Shaun Hastings was saved from Abstergo agents by Rebecca Crane, after Hastings leaked classified Abstergo Industries documents to Wikileaks. She managed to hack the computer system of the van she was held in, and saved Hastings during a gas stop.
- December 14: Subject 15 of the Animus Project, a pregnant woman, was eliminated after Lucy Stillman discovered there were dangerous complications due to the genetic memories of Subject 15's child overlapping with her own.
- February 1: Clay Kaczmarek was captured by the Lineage Discovery and Acquisition department of Abstergo Industries and became Subject 16 of the Animus Project, as planned by William Miles.
- Abstergo Industries' synthetic drug New Fluoride was introduced to the water supplies of various settlements in China and the small United States town of Prince George. Despite Susan Drayton's failed attempt at leaking a sample of the drugs, news of the operation still reached the press.
- August 8: Clay Kaczmarek committed suicide in the Animus laboratory in the Abstergo Campus. Using his blood, he painted several cryptic messages in the laboratory, and preserved his consciousness in an artificial intelligence inside the Animus.
- September 1: Desmond Miles was kidnapped near Washington Square Park in New York City by agents of Abstergo Industries, and was brought to the Abstergo Campus in Rome, Italy.
- September 2: Desmond Miles was placed inside the Animus by Warren Vidic and Lucy Stillman in the laboratory of the Abstergo Campus and became Subject 17 of the Animus Project, to relive the memories of Altaïr Ibn-La'Ahad.
- September 7: A team of Assassins attempted to rescue Desmond Miles from Abstergo's Rome facility on Lucy Stillman's request, but ended up being exterminated.
- September 8: Desmond Miles and Lucy Stillman escaped the Abstergo Campus in Rome, which was staged by Warren Vidic, after Desmond was done reliving Altaïr Ibn-La'Ahad's memories.
- September 9: Lucy Stillman and Desmond Miles arrived at an Assassin hideout in Rome, where they met with Shaun Hastings and Rebecca Crane; Desmond started reliving the memories of Ezio Auditore da Firenze in the Animus 2.0.
- September 12: A team of Assassins in Whistler, Canada was exterminated by Abstergo agents led by Daniel Cross.
- September 15: Warren Vidic led an Abstergo attack on the Assassin hideout in Rome. The Assassins managed to escape, but Abstergo retrieved the Animus recordings left behind by Lucy Stillman.
- September 16: Lucy Stillman's Assassin team arrived at Monteriggioni and set up a headquarters in the Sanctuary beneath the Villa Auditore, after a roadblack in Grosseto prevented them from reaching the Assassin cabin in the Swiss Alps.
- October 10: Desmond Miles recovered Ezio Auditore da Firenze's Apple of Eden from the Colosseum Vault, where Juno forced him to kill Lucy Stillman, realizing that she would bring the artifact back to the Templars; Desmond entered a coma from shock, and was placed in the Animus after his father William Miles recovered him.
- October 30: Desmond Miles awoke from his coma, with aid from an AI construct of Clay Kaczmarek inside the Animus, and used the Apple of Eden to enter the Grand Temple with William Miles, Shaun Hastings and Rebecca Crane an hour later; there, Juno forced him to relive the memories of Haytham Kenway and Ratonhnhaké:ton.
- November 16: Desmond Miles retrieved a power source for the Grand Temple from an office building in Manhattan, where he met and knocked out Daniel Cross.
- November 28: An Assassin team led by Harlan Cunningham infiltrated the Abstergo Campus in Rome, killing four hackers trying to track down William Miles' team, and destroyed the facility's servers.
- November 30: Abstergo's Sigma team, led by Juhani Otso Berg, attacked the Assassin hideout in Florence, which was blown up by the Assassin cell's leader Adriano Maestranzi. Berg and Harlan Cunningham were the only survivors.
- December 2: Desmond Miles retrieved the second power source for the Grand Temple at a mixed martial arts event in São Paulo, Brazil, where he took it from Daniel Cross.
- December 12: William Miles was captured by Abstergo's Sigma team led by Juhani Otso Berg in Cairo, Egypt while recovering the third power source for the Grand Temple from the Egyptian Museum.
- December 14: Desmond Miles killed Warren Vidic and Daniel Cross at the Abstergo Campus in Rome while rescuing William Miles. Vidic's death forced the launch of Eye-Abstergo to be put on hold.
- December 20: Desmond Miles, William Miles, Shaun Hastings and Rebecca Crane retrieved the Grand Temple's key from the grave of Connor Davenport in the Davenport Homestead.
- December 21: Desmond Miles sacrificed himself by touching the Eye, against the wishes of Minerva, saving the world from destruction by the incoming solar flare, though also releasing Juno from imprisonment in the Grand Temple; fifteen hours later, his body was recovered by Abstergo agents.
- May 21: Gavin Banks of the ship Altair II received William Miles' codex, wherein William had written all his knowledge and named Gavin the new leader of the Assassin Brotherhood.
- October: MysoreTech employee Jot Soora was assigned to test the Brahman V.R., an adaption of the Animus glass developed by Abstergo Industries for release on the Indian market by MysoreTech; secretly, it extracted the genetic memories of its users.
- October 29: An unidentified research analyst was assigned by Abstergo Entertainment to explore the memories of Edward Kenway as part of the Sample 17 Project in their Montreal facility.
- November 3: Jot Soora was abducted by the Assassins Siobhan and Jasdip Dhami in Mumbai, after lying to Siobhan that he was the descendant of Arbaaz Mir; Abstergo raided the compound they were hiding in, resulting in Siobhan's death.
- November 4:
- Monima Das, descendant of Arbaaz Mir and Pyara Kaur and fiancée of Jot Soora, and two Assassins drowned in the river after crashing from the Mumbai Pune Expressway amidst an Abstergo attack.
- Abstergo agents led by Juhani Otso Berg raided the Assassin hideout in the Chor Bazaar in Mumbai, resulting in the death of Dinesh and several Abstergo agents; their captive Jot Soora managed to escape.
- November 5: The Abstergo Entertainment research analyst hacked the computer of Olivier Garneau, CCO of Abstergo Entertainment, at the request of John and delivered an email conversation about a shareholders meeting in Chicago to Shaun Hastings and Rebecca Crane.
- November 18: Abstergo Entertainment detained three employees in the Bunker on suspicions of hacking into company computers. With aid from John, the unidentified research analyst hacked into the facility's server; there, they met Juno, who intended to occupy the analyst's body but explained it was too early.
- November 26: John, secretly a Sage, was killed by Abstergo Entertainment guards inside the Bunker of their Montreal facility, after having poisoned the unidentified research analyst.
- December 17: The Assassin crew of the Altair II joined up with the Assassin cell in Osaka, who had taken up the guise of the Yakuza gang Onmoraki-Gumi, under the new leadership of Saeko Mochizuki, following the death of her husband Kenichi Mochizuki after an Abstergo attack.
- January 21: Melanie Lemay was promoted to the new Chief Creative Officer of Abstergo Entertainment, starting in March, following Olivier Garneau's disappearance.
- February: The Assassins Harlan Cunningham and Arend Schut stole the Precursor box from an Abstergo Industries facility in Rotterdam. Abstergo's Sigma Team managed to recover the artifact, but the Assassins managed to escape.
- March 16: The Assassin crew of the Altair II met with Galina Voronina, a member of the Assassin cell in the science city of Protvino, south of Moscow, who revealed that her cell had gone crazy from the Bleeding Effect in the Animus.
- March 20: Galina Voronina, supported by the crew of the Altair II, exterminated the last members of her cell, including her own sister and mother, who was hooked up to the Animus and connected to Juno.
- May 7–13: Crewmembers of the Altair II were interrogated in William Miles' bunker in Tromsø, Norway to flush out a spy who had been sending coded messages to the Initiates, a hacker group.
- May: Juhani Otso Berg travelled to Essen, Germany to find the Ankh of Isis. Believing the lead to be a dead end, Berg abandoned the search and left for Cuba.
- May 23: Eric Cooper and Stephanie Chiu were discovered to be Initiate spies by the Assassins, and the Assassins tried to form an alliance with the Initiates.
- May 25–30: Juhani Otso Berg led a Templar expedition in Jamaica to find the Observatory. After several days of digging, Berg concluded that the temple suffered a catastrophic collapse in the 18th century and was deliberately buried by the Assassins.
- June 16: Shaun Hastings sent a message to members of the Initiates, imploring them to work with the Assassins.
- October: A team of Assassins led by Gavin Banks destroyed an Abstergo Industries laboratory in Paris. Sigma Team followed the Assassins to La Rochelle, where the Assassins escaped on the Altair II.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 1.18 1.19 1.20 1.21 1.22 1.23 1.24 1.25 1.26 1.27 1.28 1.29 1.30 1.31 1.32 1.33 1.34 1.35 1.36 1.37 1.38 1.39 1.40 1.41 1.42 1.43 1.44 1.45 1.46 1.47 1.48 1.49 1.50 1.51 1.52 1.53 1.54 1.55 1.56 1.57 1.58 1.59 1.60 1.61 1.62 1.63 1.64 1.65 1.66 Assassin's Creed II
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 2.15 2.16 2.17 2.18 2.19 2.20 2.21 2.22 2.23 2.24 2.25 2.26 2.27 2.28 2.29 2.30 2.31 2.32 2.33 2.34 2.35 2.36 2.37 2.38 2.39 2.40 2.41 2.42 2.43 2.44 2.45 2.46 2.47 2.48 2.49 2.50 2.51 2.52 Assassin's Creed III
- ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 3.16 3.17 3.18 3.19 3.20 3.21 3.22 3.23 3.24 3.25 3.26 3.27 3.28 3.29 3.30 3.31 3.32 3.33 3.34 3.35 Assassin's Creed: Revelations
- ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 4.15 4.16 4.17 4.18 4.19 Assassin's Creed Encyclopedia
- ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 5.12 5.13 5.14 5.15 5.16 5.17 5.18 5.19 5.20 5.21 5.22 5.23 5.24 5.25 5.26 5.27 5.28 5.29 5.30 5.31 5.32 5.33 5.34 5.35 5.36 5.37 5.38 5.39 5.40 5.41 5.42 5.43 5.44 5.45 Assassin's Creed: Initiates
- ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 6.12 6.13 6.14 6.15 6.16 6.17 6.18 6.19 6.20 6.21 6.22 6.23 6.24 6.25 6.26 6.27 6.28 6.29 6.30 6.31 6.32 Assassin's Creed: Brotherhood
- ↑ 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 7.12 7.13 7.14 7.15 7.16 7.17 7.18 7.19 7.20 7.21 7.22 7.23 7.24 7.25 7.26 7.27 7.28 7.29 7.30 7.31 7.32 7.33 7.34 7.35 7.36 7.37 Assassin's Creed: Project Legacy
- ↑ Assassin's Creed 1: Desmond
- ↑ 9.0 9.1 9.2 Assassin's Creed 2: Aquilus
- ↑ 10.0 10.1 10.2 10.3 Assassin's Creed 3: Accipiter
- ↑ 11.00 11.01 11.02 11.03 11.04 11.05 11.06 11.07 11.08 11.09 11.10 11.11 11.12 11.13 11.14 11.15 11.16 11.17 11.18 11.19 11.20 11.21 11.22 Assassin's Creed: The Secret Crusade
- ↑ 12.0 12.1 12.2 12.3 12.4 12.5 12.6 12.7 12.8 Assassin's Creed: Altaïr's Chronicles
- ↑ 13.00 13.01 13.02 13.03 13.04 13.05 13.06 13.07 13.08 13.09 13.10 13.11 13.12 13.13 13.14 Assassin's Creed
- ↑ 14.0 14.1 14.2 14.3 14.4 14.5 14.6 14.7 14.8 Assassin's Creed: Bloodlines
- ↑ 15.00 15.01 15.02 15.03 15.04 15.05 15.06 15.07 15.08 15.09 15.10 15.11 15.12 15.13 15.14 Assassin's Creed: Memories
- ↑ 16.0 16.1 16.2 Assassin's Creed 4: Hawk
- ↑ 17.0 17.1 17.2 17.3 17.4 17.5 17.6 Assassin's Creed: Revelations novel
- ↑ 18.00 18.01 18.02 18.03 18.04 18.05 18.06 18.07 18.08 18.09 18.10 18.11 18.12 18.13 18.14 18.15 18.16 18.17 18.18 18.19 18.20 18.21 18.22 18.23 18.24 18.25 18.26 18.27 Assassin's Creed: Unity
- ↑ 19.00 19.01 19.02 19.03 19.04 19.05 19.06 19.07 19.08 19.09 19.10 Assassin's Creed: Revelations – Discover Your Legacy
- ↑ 20.0 20.1 Assassin's Creed 5: El Cakr
- ↑ 21.00 21.01 21.02 21.03 21.04 21.05 21.06 21.07 21.08 21.09 21.10 21.11 21.12 21.13 21.14 21.15 21.16 21.17 21.18 21.19 21.20 21.21 21.22 21.23 21.24 21.25 21.26 21.27 21.28 21.29 21.30 Assassin's Creed: Rogue
- ↑ 22.0 22.1 22.2 22.3 Assassin's Creed: Recollection
- ↑ Assassin's Creed: Lineage
- ↑ 24.0 24.1 24.2 24.3 24.4 24.5 24.6 24.7 24.8 Assassin's Creed II: Discovery
- ↑ 25.0 25.1 25.2 25.3 Assassin's Creed: Renaissance
- ↑ 26.0 26.1 Assassin's Creed: Ascendance
- ↑ Assassin's Creed: Brotherhood – Copernicus Conspiracy
- ↑ 28.0 28.1 28.2 28.3 28.4 Assassin's Creed: Brotherhood novel
- ↑ 29.0 29.1 29.2 29.3 29.4 29.5 29.6 29.7 29.8 Assassin's Creed Chronicles: China
- ↑ 30.0 30.1 30.2 Assassin's Creed: Embers
- ↑ 31.00 31.01 31.02 31.03 31.04 31.05 31.06 31.07 31.08 31.09 31.10 31.11 31.12 31.13 31.14 31.15 31.16 31.17 31.18 31.19 31.20 31.21 31.22 31.23 31.24 31.25 31.26 31.27 31.28 31.29 31.30 31.31 31.32 31.33 31.34 31.35 31.36 31.37 31.38 31.39 31.40 Assassin's Creed IV: Black Flag
- ↑ 32.0 32.1 32.2 32.3 32.4 32.5 32.6 Assassin's Creed: Pirates
- ↑ 33.0 33.1 Assassin's Creed: Black Flag
- ↑ 34.0 34.1 34.2 34.3 34.4 Assassin's Creed IV: Black Flag – Freedom Cry
- ↑ 35.0 35.1 35.2 35.3 35.4 35.5 35.6 35.7 35.8 Assassin's Creed: Forsaken
- ↑ 36.00 36.01 36.02 36.03 36.04 36.05 36.06 36.07 36.08 36.09 36.10 36.11 36.12 36.13 36.14 Assassin's Creed III: Liberation
- ↑ Assassin's Creed III – George Washington's notebook
- ↑ Assassin's Creed III – The Tyranny of King Washington
- ↑ 39.0 39.1 39.2 39.3 39.4 Assassin's Creed: Unity – Dead Kings
- ↑ 40.0 40.1 40.2 40.3 40.4 40.5 40.6 Assassin's Creed: Brahman
- ↑ 41.0 41.1 41.2 41.3 41.4 41.5 Assassin's Creed: Revelations – The Lost Archive
- ↑ 42.00 42.01 42.02 42.03 42.04 42.05 42.06 42.07 42.08 42.09 42.10 42.11 42.12 Assassin's Creed: The Fall
- ↑ 43.0 43.1 43.2 43.3 Assassin's Creed: The Chain
- ↑ 44.0 44.1 Assassin's Creed: Revelations – AbstergoIndustries.com