The episode took place a few months after the supposed events of Assassin's Creed III, after the British were defeated and the Colonies were granted independence.
Ratonhnhaké:ton was awoken up by his mother, Kaniehtí:io, who alerted him to a threat in the forest. He followed her, questioning why she was alive and what was going on. They met a Bluecoat ambush attacking villagers. After dispatching the ambush, a woman warned Kaniehtí:io that King George was looking for her.
Kaniehtí:io led Ratonhnhaké:ton to the top of the hill, while Ratonhnhaké:ton questioned his surroundings, and why the woman referred to George Washington as "King."
As they reached the top of the hill, they witnessed a group of Bluecoats forcing the townspeople into the church and barricading the door. The Bluecoat leader demanded that the townspeople inform him of the location of Kaniehtí:io. As the townspeople insisted they did not know her location, the Bluecoats set fire to the church. Ratonhnhaké:ton and his mother quickly ambushed Washington's men, and liberated the townspeople, only for a cannon ball blast to kill the group before they could escape.
Later, they returned to their village, where they met another Bluecoat attack. King Washington, accompanied by Benedict Arnold and General Putnam, killed Ratonhnhaké:ton's mother with a scepter containing an Apple of Eden. Ratonhnhaké:ton fought Washington, only to be defeated by the Apple from which his power originated, and was later shot and stabbed; consequently, he slipped into a state of unconsciousness. When Ratonhnhaké:ton awoke in a cave, five months had passed and Clan Mother told Ratonhnhaké:ton what happened. She noted that he wasn't surprised at witnessing his mother's death; in fact, she stated that he took her murder very well. Ratonhnhaké:ton was then told by the Clan Mother to climb the Red Willow, pick its virgin branches, and drink the willow's tea. He heeded her instruction and soon gained the ability to become invisible at will, as well as summon a group of wolves to ambush his enemies. Shortly thereafter, he was requested by one of his fellow tribesmen to assist in finding and rescuing his brother. The two tracked his brother and discover that he was tied up along with other members of the village, who were lined up to be executed. Once Ratonhnhaké:ton's tribe members were liberated, he was instructed to return to the Clan Mother for further instruction.
When he returned to their hideout, he discovered all of the villagers had been killed, and a dying Clan Mother. In her last instructions to Ratonhnhaké:ton, she told him to kill Washington, as well as Israel Putnam and Benedict Arnold, finishing what his mother started. Ratonhnhaké:ton trailed Israel Putnam to a large fortress and discovered Benedict in the center of the stronghold. Once his guards had been defeated, he confronted Benedict Arnold and mortally wounded him. Before he died, Arnold told him to free and then talk to Benjamin Franklin in Boston. Unbeknownst to Ratonhnhaké:ton, Putnam approached from behind and hit Ratonhnhaké:ton in the head with his pistol, rendering him unconscious. Once fully awake, Ratonhnhaké:ton realized that he had been captured and transported in a convoy heading for Boston. Putnam revealed his intentions of taking Boston, claiming that it was as good as done, through him presenting Ratonhnhaké:ton's head to Washington as a gift.
- The Infamy DLC suffers from a game-breaking bug during the last memory. In the section where the player is meant to stalk the patrol dogs, the animals sometimes do not spawn, rendering the rest of the memory unplayable. No known fix has been implemented as of June 2017.