The simulation depicted the Piazza del Campo, one of Siena's most recognizable plazas, featuring notable landmarks such as the Palazzo Pubblico and its Torre del Mangia. The Palio di Siena, a traditional medieval horse race that occurred twice a year, was apparently on-going, as horses could occasionally be seen running past. The area had a festive, busy air, with many colorful lanterns and flags strung up as visitors watched the Sienese performers. A slightly more relaxing sight was the Fonte Gaia, a medium-sized fountain that was located at the edge of the plaza.
Siena was not programmed to have aesthetic variations. As a result, it could only be used during the late evening.
- Siena was the last name and place of origin of various Borgia captains, who shared the trait of fleeing to safety if they spotted the Assassin Ezio Auditore da Firenze during the liberation of Rome.