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By 2012, the Assassins had a safehouse located in the city. On 19 December of that year, following William Miles' instructions, Harlan Cunningham left for the safehouse following the destruction of the Florence safehouse.
In February 2014, Cunningham and his partner Arend Schut infiltrated an Abstergo Industries facility in Rotterdam and stole the Precursor box. After a firefight with Juhani Otso Berg's Sigma Team, Cunningham and Schut were forced to leave the artifact behind in order to escape.