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In 2012, Desmond and William Miles had to retrieve three power sources located in different cities around the world. For the first one, Desmond traveled to New York City, climbing a tower and parachuting onto the one that contained the power source. After he retrieved it, he was confronted by the Templar Daniel Cross, who he knocked out with the artifact.
The second artifact was in possession of a woman who was spectating a mixed martial arts tournament in São Paulo, Brazil. Desmond went to the room she was in, but saw that Daniel Cross had made it there first and killed the woman, taking the artifact. He ran out of the room and tried to escape, but Desmond eventually caught up to him and took the power source from him after a fist fight.
The third power source was located in a museum in Cairo, Egypt. Desmond was prepared to retrieve it, but was told he needed to stay and find the Grand Temple Key through Ratonhnhaké:ton's genetic memories. William then left for Cairo to acquire it in his stead, but was later captured by Sigma Team.