The bridge was built to cross the river from the city center to Emperor Hadrian's mausoleum, which later became the Castel Sant'Angelo.
In 1450, its balustrades buckled due a surging mob of pilgrims making their way to the St. Peter's Basilica, leading to a mass drowning. Later, in the 16th century, the structure was used to display the bodies of executed men to the public.
- The bridge was a restricted area in Brotherhood, except in certain memories, such as "The Ezio Auditore Affair".
- The bridge was formerly known as Pons Aelius or Ponte Aelius.
- Historically, the statues on the bridge were not placed until 1527 by order of Pope Clement VII.