Piero de' Medici (15 February 1472 – 28 December 1503), often called Piero the Unfortunate (Italian: Piero il Fatuo) to distinguish him from his grandfather, was the son of Lorenzo de' Medici and Signore of Florence from 1492 until 1494.
In 1494, Piero de' Medici was exiled by Girolamo Savonarola, who had gained control over Florence using an Apple of Eden. As a result, Piero fled to Venice, where Savonarola's supporters were also attempting to spread their leader's influence.
Irritated at the prospect, Piero stood up to one of these heralds, causing a brawl between him and Savonarola's followers. However, before Piero could be killed by the herald, he was aided by Ezio Auditore da Firenze, a friend of his late father; the pair quickly parted ways again when Ezio embarked to Florence to take down Savonarola's rule.
- Piero was a student and possible murderer of his teacher Poliziano through the use of arsenic poisoning.
- A database image found inside the files of Assassin's Creed II suggests that Piero was originally set to appear in the game.