Sometime between 1481 and 1488, Girolamo Riario sent some of his men to ransack the Palazzo Pitti. These men killed some of the palace's residents and stole a valuable map, before returning to Girolamo in Forlì.
Soon after, Lorenzo de' Medici contacted the Assassin Ezio Auditore da Firenze via pigeon coop while he was in Forlì, explaining to him what had had happened. With this knowledge, Ezio hunted down and killed Girolamo's men.
During the Bonfire of the Vanities, Girolamo Savonarola took up residence in the Palazzo after taking over Florence in 1494, and made it his primary residence. In 1498 however, the people of Florence, fed up his anti-materialist laws, gathered in a mob in front of the Palazzo Pitti.
Powerless, Savonarola was captured by the mob and carried to the Palazzo della Signoria to be burned at the stake.
- Historically, Girolamo Savonarola lived in the Chiesa di San Marco (Church of San Marco) after he took over Florence. The Palazzo Pitti would still have been in the possession of the Pitti family at the time.