Osaka is the third largest city by population that is located in the country of Japan.
As of the year 2012, there was known to be an Assassin cell located in the city. However, they were tailed by Abstergo Industries and planned to cut off all contact with the Assassin headquarters until losing them, before they would re-establish it 72 hours later. As planned, the cell made contact with Gavin Banks, having lost their tail and relocated to a safehouse that the Assassin Order had not used since 1998. However, when Gavin entered the safehouse, alongside Emmanuel Barraza, he realized that they had been taken out by the yakuza.