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Working for the Metropolitan Police Service, Detective Murphy was a good friend of Sergeant Frederick Abberline. In 1868, he received a tip about several disappearances occurring around Fleet Street in Whitechapel. Murphy went to investigate, questioning the florist, barber, baker and leatherworker in the area.
Unbeknownst to him, the leatherworker, Tobias Jeffers, was behind the disappearances. Feeling that the detective was coming too close to the truth, Jeffers killed Murphy, flayed him, and made a handbag out of his skin. His bones were then ground up into manure, and his meat was sold to the bakery for the creation of meat-pies.
The Assassins Jacob and Evie Frye investigated Detective Murphy's disappearance. After questioning several suspects and uncovering many clues all around Fleet Street, they managed to accuse Jeffers of his crimes and have him arrested by the authorities.