Moscow is the largest and capital city of Russia.
Historically, it has been linked to the struggle between Assassins and Templars since before the Renaissance. In modern times, it has been the seat of power for many Templar-influenced rulers, ranging from Alexander III to Vladimir Putin.
During his time in Rome at the height of the Renaissance, Ezio Auditore da Firenze sent a team of apprentices to Moscow to keep an eye on Ivan III Vasilevich. They started by investigating the disappearance of Pietro Antonio Solari, a fellow Assassin who had vanished while working as an architect on the Kremlin. They discovered a vault with records that revealed Solari had been murdered by another Italian, known only as "Aristotele".
They decided their best option was try finding Aristotele and began their search at the Kremlin. After having questioned several people, they were directed towards a church, where they eventually found the man they were looking for, Ridolfo Fioravant. Ridolfo revealed to them that Ivan was close to discovering the presence of the Assassin Order, and that he had been forced to deceive him.
The Assassins then decided to make Ivan believe in a cult that did not exist, the Strigolniki Sect. They forged documents and spread them among the population, causing paranoia in the citizens of Moscow. Because of this, Ivan soon gave up on his investigation into the Brotherhood and began investigating the Strigolniki Sect instead.
After the Templar puppet Joseph Stalin gained control of Russia in 1922, he helped orchestrate World War II by using fear tactics, secret police, and brutal political purges; to this end, Moscow became a symbol of the communist threat throughout the Cold War. Faced with intense persecution, the Assassins working out of Moscow either split into separate cells or were killed. As of 1977, there were at least two independently-operating cells in the city, neither of which knew about the other.
That year, an Assassin scientist working out of a laboratory in nearby Protvino met William Miles in the city zoo, and was given a stolen copy of a prototypical Animus' blueprints. Miles instructed the scientist to build the machine before Abstergo Industries could before he departed to meet with one of the city's Assassin cells.
In 2002, Daniel Cross infiltrated the library of Ivan the Terrible, which was hidden beneath the Bolshoi Theatre in the city. He had posed as a replacement for the Assassin guarding it, and following this, he opened the Prophet's Codex and read Minerva's speech to Warren Vidic via his earpiece, before taking it with him back to Abstergo and killing the Assassin sentry.
In March of 2014, the Russian Assassin Galina Voronina met Gavin Banks, Emmanuel Barraza, and Emmett Leary in the city, to discuss the possibility of assassinating her mother, the scientist who had built the Animus based off of the blueprints William Miles had stolen in 1977.