- "I feel the world flying by and I need to catch it, to become part of its tides and currents."
- ―Michelangelo, in a letter to his father.[src]
In the message, Michelangelo revealed that he had abandoned his schooling almost a week previous, as he had "felt the world flying by," and desired to be a part of it. He stated that he wanted to live up to his father's expectations, but also asked for his blessing to become an artist, an occupation his father greatly disapproved of.
At that time, Domenico Ghirlandaio had just invited Michelangelo to join him as an apprentice, and Michelangelo praised the "masterful work" he had done in the Sistine Chapel, wishing he would be able to see it one day.
By 1511, Michelangelo had become a good friend of Ezio Auditore.
- Michelangelo is represented in the Artists mnemonic set in Assassin's Creed: Project Legacy.
- Though developers commented on the iconic experience of freerunning past Michelangelo's fresco on the Capella Sistina ceiling, it was not present within the timeframe of Assassin's Creed II, and so it was not included.