Medusa was the most famous incarnation of the Writhing Dread, and by extension, the gorgons, a type of hybrid beast created by the Isu as part of the Olympos Project. Medusa was originally a human but taken over by an Atlantis artifact, known as the Prize of the Medusa, to act as a guardian for it, in order to seal the Gates of Atlantis.
In Greek mythology, she was described as having had hair composed of live venomous snakes, wings and a visage so monstrous that all who beheld it turned into stone. According to the myth, she was slain by the Mycenaean founder Perseus with a Sword of Eden.
- A rare heavy weapon acquired by the Medjay Bayek of Siwa in Cyrene in 47 BCE was named after Medusa, owing to her ferocity.
- Assassin's Creed III: Liberation (mentioned only)
- Assassin's Creed: Origins (mentioned only)
- Assassin's Creed: Odyssey (statue only)