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Manuel may refer to:
- Manuel I of Portugal, the 14th King of Portugal who allied himself with the Templars in Assassin's Creed: Brotherhood
- Manuel Palaiologos, heir to the Byzantine Empire throne and a character in Assassin's Creed: Revelations
- Manuel Tadros, a Canadian voice actor who provides the voice for Rodrigo Borgia in Assassin's Creed: Lineage, Assassin's Creed II, and Assassin's Creed: Brotherhood