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Manco Inca Yupanqui (1516 – 1544) was the founder of the Neo-Inca State, which he ruled from 1533 to his death. Formerly thought to be a puppet of the Spanish Empire, Manco revolted against the conquistador and in 1536 was besieging the Spanish-occupied Cuzco.
That same year the chasqui Quila discovered an assassination plot against him, and tried to warn her Emperor, but failed. With the help of an Assassin, Gonzalo Pardo, Quila still discovered the identity of the traitor, her former father-in-law, the high ranking official Tuti Cusi. Pardo, Quila and her former husband, Ayar, eventually saved Manco, stopping the attempt during Inti Raymi ceremonies and unveiling Tuti Cusi's alliance with the Spanish. Grateful, Manco then promoted Quila as his personal messenger and asked his men to bow to her.
- Assassin's Creed #010