During the time of the mid-Renaissance, London was ruled by King Henry VII of England. During the late 15th century, the Templars made attempts to obtain the English throne. However, their plans were thwarted by Henry VII, as he imprisoned Lambert Simnel and had Perkin Warbeck hanged. In 1503, Ezio Auditore da Firenze, Mentor of the Italian Assassins, sent a group of his apprentices to London in order to aid King Henry VII. They subsequently killed Warbeck and Simnel's co-conspirator Margaret of York in November of 1503.
Afterwards, the apprentices killed several Templars instigating riots over Margaret's death. One such Templar revealed that their Order had infiltrated Henry's Star Chamber, to which the apprentices quickly searched for the infiltrators; they found a group of Englishmen signing Borgia documents and eliminated them. As a reward, King Henry offered the Assassins a seat in the Star Chamber.
In 1660, Charles Stuart was invited to London to be crowned King after having been exiled by Oliver Cromwell for several years. At his crowning, Stuart noticed a man holding a sphere wrapped in a thick piece of cloth talking with his General, George Monck.
London later burned to the ground from September 2-5 1666, in what is now known as the Great Fire of London, which gutted the medieval City of London inside the old Roman city wall. It threatened, but did not reach, the aristocratic district of Westminster, Charles II's Palace of Whitehall, and most of the suburban slums. It consumed 13,200 houses, 87 parish churches, St. Paul's Cathedral, and most of the buildings of the City authorities. It is estimated to have destroyed the homes of 70,000 of the City's 80,000 inhabitants. The death toll is unknown but traditionally thought to have been small, as only six verified deaths were recorded. This reasoning has recently been challenged on the grounds that the deaths of poor and middle-class people were not recorded, while the heat of the fire may have cremated many victims leaving no recognizable remains.
Following his time as a privateer-turned-pirate in the Caribbean, the Assassin Edward Kenway retired to a spacious mansion on Queen Anne's Square, in Bloomsbury, with his wife Tessa, son Haytham, and daughter Jenny. On 3 December, 1735, mercenaries hired by the Templar – and family friend – Reginald Birch attacked their home, murdering Edward and kidnapping Jenny. Birch then took Haytham in, training him to become a Templar.
In 1754, Haytham attended a performance of The Beggar's Opera at the Theatre Royal to find and kill the Assassin Miko, an act which saw Assassin influence in the city collapse entirely for the next 114 years. Haytham recovered an artifact for Birch, who believed it was a key to a Precursor site in North America: Haytham set sail for Boston on the Providence. Meanwhile, Miko's murder became public news and left many civilians wondering whether to leave the city or not.
During the 18th century, the Templars were able to gain complete control of the city and kept it under their thumb well into the 19th century.
- "Today, Starrick sits at the helm of the most sophisticated Templar infrastructure known in the western world. Every class, every borough, the gangs, the industries - his reach extends all across London. [...] Look at what Starrick has done to this city. Whitechapel is riddled with crime. Child labor, despite regulations. A gang known as the Blighters overruns the streets. And Templars manipulating behind the scenes. As in all the other boroughs. We need to return this city to the people who built it in the first place."
- ―Henry Green describing the state of London, 1868.[src]
By the 19th century, under Queen Victoria's rule, London became the global capital of invention with its technological advancement. It was divided into seven boroughs - the City of London, Lambeth, The Strand, Westminster, Southwark, Whitechapel, and the River Thames - each with a different culture but with a single commonality. As country folk moved in to the city for employment, however, it resulted in a sudden increase in population and decrease in wages, in addition to most businessmen abusing workers. These actions became a spark for the Industrial Revolution.
By 1868, London had fell under the control of the Templar Grand Master Crawford Starrick, who used his network of Templar agents to control the city and oppress the working classes to keep the Templars in power. The British Assassins, particularly Henry Green worked to reclaim power in the city. He enlisted the aid of the fraternal twins Jacob and Evie Frye, who created the gang known as the Rooks to remove the influence of the Templar-backed gangs throughout London.
In 1916 during the First World War, a German individual and a Sage known as the Master Spy infiltrated London, setting up a spy network near the Tower Bridge as well as a localized cult in service of Juno. Winston Churchill caught wind of his activities and enlisted the help of the Assassin Lydia Frye, who succeeded in repelling the enemy planes and eliminating the spy cell. 
In 2016, after discovering Aguilar's Apple, Alan Rikkin called a meeting with the Council of Elders in London at the Grand Templar Hall. While presenting the Apple's abilities, Alan was assassinated by Callum Lynch who took the Apple and fled.
In 2018, Layla Hassan and her team were stationed in a loft apartment in London while searching the memories of the Spartan misthios Kassandra in order to locate more Isu artifacts before Abstergo could. Kiyoshi Takakura, a member of the team kept watch from outside. Eventually the location had been compromised and as a parting gift to Abstergo, Layla left a USB drive at the apartment that could be remotely detonated by her.
- There are light bulb advertisement signs on some buildings in Assassin's Creed: Syndicate, though this is anachronistic as electric lighting was first used in 1883 in Holborn. The first light bulb advertisement signs didn't appear until at least the 1890s.
- Many of the roofs of the buildings in Assassin's Creed: Syndicate, are in the Mansard style. This style spread to Britain in the 18th century. Some of the roofs are covered with metal tiles, either lead, corrugated iron, a method originally patented in England in 1829 or zinc galvanized metal, a method developed in France in 1837 and which became popular in Victorian times, because of its cheapness when compared with lead.
- ↑ 1.0 1.1 Assassin's Creed: Brotherhood – Contracts
- ↑ 2.0 2.1 Assassin's Creed: Project Legacy – Contracts
- ↑ Assassin's Creed: Project Legacy – Holidays: Chapter 1 - Ghosts of Christmas Past
- ↑ 4.0 4.1 Assassin's Creed: Forsaken
- ↑ 5.0 5.1 Assassin's Creed III
- ↑ 6.0 6.1 6.2 Assassin's Creed: Syndicate
- ↑ The Network Podcast - Episode 13
- ↑ Assassin's Creed official website
- ↑ GameInformer: Five Things to Know About Assassin's Creed: Syndicate
- ↑ A Brief History of London, England. www.localhistories.org. Accessed 1 October 2017.
- ↑ See Photos Of London When Queen Victoria Was Ruling. Londonist Ltd. Accessed 1 October 2017.
- ↑ ROOFS A Guide to Alterations and Extensions on Domestic Buildings. City of Westminster Department of Planning and City Development, Development Planning Services, March 1995. Accessed 22 October 2017.
- ↑ London Terrace Houses 1660-1860. English Heritage, 23 Savile Row, London W1X 1AB 0171 973 3434 February 1996. Accessed 22 October 2017.
- ↑ London: An Architectural History by Anthony Sutcliffe. Yale University Press New Haven and London. Accessed 22 October 2017.
- ↑ Preservation Bried 4: Roofing for Historic Buildings by Sarah M. Sweetser. www.nps.gov. Accessed 22 October 2017.
- ↑ Understanding Housing Defects by Duncan Marshall, Derek Worthing, Roger Heath, Nigel Dann. Routledge 2 Park Square, Milton Park, Abingdon, Oxon OX14 4RN. Accessed 22 October 2017.