Lisbon (Portuguese: Lisboa) is the capital city of Portugal. During the Renaissance, a guild of the Assassin Order was based in the city and received aid from Ezio Auditore da Firenze's Italian guild.
Knowing that Manuel might have connections to the Templars, the Assassins traveled to Lisbon and interrogated one of the men in his council, who revealed that Manuel did indeed serve the Templar cause. They also learned that Manuel was preparing to send a fleet, led by Vasco da Gama, to Calicut. This prompted the Assassins to warn their brothers in India.
Shortly after that, they learned that Manuel was forcing all Jewish people to either convert to Christianity or leave the city, but had also closed the city borders, making it impossible to escape. Anyone who refused to convert was beaten or even killed. The Assassins arranged for three ships to take the Jewish citizens out of Lisbon, though it was not enough and the Assassins were forced to kill many guards that had found out about their plans.
Knowing that they could not get all the citizens out in time, they provided them with weapons and light armor, training them in tactics such as stealth, surprise, intimidation and shock. The civilians seemed eager to fight their king, as very little of them accepted the offer to travel to Italy with the Assassins.
In November of 1755, the then-Assassin Shay Cormac was sent to Lisbon by his Mentor, Achilles Davenport to retrieve a Piece of Eden inside a First Civilization Temple below the Carmo Convent. When Shay had removed the Piece from it's pedestal, the defense mechanisms of the Piece triggered a massive earthquake in the city, collapsing structures and killing civilians. Shay managed to escape from the disaster, and sailed back to the Thirteen Colonies.