In 48 BCE, the MedjayBayek of Siwa travelled across the lake in search of Klaudios, an Alexandrian man who had gone missing from Yamu. There, he found Klaudious stranded on a column from an island ruin, surrounded by a pack of crocodiles. Bayek was able to eliminate the crocodiles and escorted Klaudious back to Yamu.
Later, he returned to the island, investigating a series of mysterious killings conducted by a cult of Serqet in the ruins.
In Origins, Lake Mareotis is displayed as a region in Egypt including the lake.