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The Italian Wars, often referred to as the Great Italian Wars or the Great Wars of Italy and sometimes as the Habsburg–Valois Wars or the Renaissance Wars, were a series of conflicts from 1494 to 1559 that involved, at various times, most of the city-states of Italy, the Papal States, most of the major states of Western Europe (France, Spain, the Holy Roman Empire, the Republic of Venice, England, and Scotland) as well as the Ottoman Empire.