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After Domenico's mentor Dante Alighieri was killed by Templars, he took Isabetta and Renato with him to journey to Spain in order to keep the codex of Altaïr Ibn-La'Ahad from the Templars. However, after leaving the Otranto harbor, their trading vessel was attacked by pirates hired by the Templars, who raped and killed Isabetta. Her body later washed up on shore, where it was discovered by her husband and son.