- "I have found the Achaemenid, and he gave me the secret of his poison. Not as fast as I would have hoped, but always fatal. Ironically, Alexander will die by the poison of those whom he had vanquished in battle."
- ―Iltani in a message for the Brotherhood.[src]
At some point during Alexander's conquest of Asia, Iltani tracked him to Herat, Afghanistan, where he was holed up in a mighty Citadel. She managed to infiltrate the Citadel, but soon realised she would not be able to take him out through force.
Instead, when she suspected Alexander had become aware of her presence, she left Herat. She set out to find an Achaemanid alchemist, hoping to expand her knowledge of poisons. After a perilous journey, she arrived in Babylon, where she found the alchemist and learned his secrets.
Before going after Alexander to perform her planned assassination, she left messages for her fellow Assassins, including the recipe of the poison, in case she would not be successful.
By the time of the Renaissance, Iltani's sarcophagus had been moved to the Basilica di Santa Maria del Fiore in Florence. Fellow Assassin Ezio Auditore da Firenze explored her tomb and took the seal from her sarcophagus, which helped him to acquire the armor of Altaïr Ibn-La'Ahad.
- Iltani is the feminine form of a Babylonian word meaning "lucky" or "favored by the god(dess)".
- It is also the Babylonian name for the north wind.