Hong Kong is a major city-state and autonomous territory of China on its southern coast facing the South China Sea. One of the most densely populated cities in the world, it lies on the east end of the Pearl River Delta across from Macau, and is one of the world's greatest financial centers of international commerce.
In 2012, the pharmacologist Stephanie Chiu fled from Abstergo Industries after discovering her father's involvement in the New Fluoride scandal. She escaped to Hong Kong, where she met the Assassins Gavin Banks and Susan Drayton, and joined the Assassin Brotherhood aboard the Altaïr II.
In February 2017, an Assassin cell led by Barindra Mitra broke into an abandoned Abstergo skyscraper office in Hong Kong. The cell assisted Charlotte de la Cruz in her efforts to gather informations about Abstergo's Phoenix Project. However, the cell was ambushed by the Instruments of the First Will led by Jasdip Dhami, with Charlotte and Guernica Moneo being the only survivors.