In 1348, the Plague crossed Essen, a town in Germany, and wiped out half of its population. Soon after this, a group called the Brothers of the Cross arrived. The Assassin Lukas Zurburg soon found out they were a Templar organization that offered protection from the plague, and he also suspected that they were after the Ankh, an artifact that was said to be located in central Europe. In 1350, both the Brothers of the Cross and Lukas disappeared.
During the period of the Italian Renaissance, apprentices from the Roman Assassins Guild traveled to Germany to have a meeting with Conradus Celtis, a scholar that had discovered the Assassin Order through his research. The Assassins persuaded him to keep his discoveries secret, to which he eventually agreed.
However, the Assassins intercepted the carriage that was to deliver the bribe, and made the Borgia believe that the money had been stolen by bandits. From there, they then used the money to make an anonymous donation to the school.
From 1914 to 1918, Germany found itself involved in World War I. One German general, the Templar Erich Albert, was the target of an unnamed British Assassin during the Christmas truce of 1914. From 1939 to 1945, Germany was involved in World War II, being one of the major countries involved, along with Italy, Japan, England, France, China, Russia, and the United States of America.
Adolf Hitler, the leader of the Nazi Party and dictator of Germany, plotted with Templars Winston Churchill, Joseph Stalin, and Franklin D. Roosevelt to form a New World Order. Through his associates, Hitler came into possession of a Piece of Eden, and during the war, he was supposed to use it to make a clone of himself that was to be left in the bunker. However, the real Adolf Hitler was assassinated and his Piece of Eden disappeared.
- In the memory The Berlin Specimen, Jacob and Evie refer to the German Dr. Schwartz' home country as Germany, this is seen by some as anachronistic because the game is set in 1868 whereas the unification of Germany did not occur until 1871, but the the term Germany was used for this area long before 1871.