In 1503, after the death of Rodrigo Borgia and Cesare's poisoning, Ezio Auditore da Firenze went to a military meeting Cesare had planned at the Campanile of Santa Maria in Trastevere. Once Ezio arrived and entered the meeting room, he found Cesare and his lieutenants making plans to kill the Assassins. However, Cesare was weakened because of the poison and was tended to by Gaspar Torella. Ezio used the Apple to kill the lieutenants, but Cesare and his doctor escaped.
After Cesare's imprisonment, Ezio and Leonardo da Vinci went to visit Gaspar at his house, hoping he could tell them more about Cesare's whereabouts. The doctor didn't know anything Ezio hadn't heard before, and was more interested in the French Disease than finding Cesare, though he did mention Ezio could do worse than looking in Spain. After this, Ezio and Leonardo left the doctor.