- "François Mackandal, my own mentor – the leader, the priest, the Brother, to whose cause I devoted my life. He was put to death by fire. I failed to prevent it."
- ―Agaté about Mackandal.[src]
François Mackandal (unknown – 20 January 1758) was a voodoo leader and the Mentor of the Assassin Brotherhood on Saint-Domingue. During his time as Mentor, he was a teacher to Agaté, who went to become the Mentor of the Assassins in Louisiana.
In 1732, François Mackandal met Agaté, Baptiste and Jeanne, who had all been transported to a plantation at Saint-Domingue. Mackandal took all three under his wing and taught them to read and write, also instructing Agaté and Baptiste on how to craft poison and use weapons. In 1738, Agaté and Baptiste joined the Assassin Brotherhood and along with Mackandal, they escaped from Saint-Domingue.
Mackandal fought with Agaté and Baptiste for many years, until a failed attempt to poison the colonists of Saint-Domingue resulted in his execution in 1758.
In 1766, Mackandal's student Baptiste impersonated him, aiming to take the Louisiana Bayou by force and continue Mackandal's mass poisoning. By 1776, Mackandal's role as Mentor in Saint-Domingue was considered a disgrace by Eseosa, and the young man strove to recreate the Order a thousand times better than the one headed by Mackandal. This led Eseosa to set up a voodoo ceremony at Bois Caman to start a rebellion.