Eve was a hybrid human-Isu who took a leading role in the human rebellion against the Isu. As a fighter for humanity's free will, she is considered one of the first proto-Assassins, along with Adam.
In 75,010 BCE, Eve rebelled against her creators, unaffected by the effects of the Isu's "Pieces of Eden" due to the lack of necessary neurotransmitters in her brain, and stole an "Apple of Eden". She then proceeded to wake another hybrid, Adam,, following which the pair attempted to escape Eden, only to be stopped by an unknown force.
Later, Eve was chosen as the official leader of humanity's rebellion against their creators, and a holographic record of her election on a Prophecy Disk survived the Toba catastrophe, until it was discovered by Aveline de Grandpré in 1777.
Eve and Adam were the parents of Cain and Abel, the former of which would later kill his brother to acquire his Apple of Eden and become the founder of the order that would come to be known as the Knights Templar.