In 1257, Darim Ibn-La'Ahad, son of the Mentor of the Levantine Assassins, Altaïr Ibn-La'Ahad, moved to Alexandria after the Levantine Assassins were disbanded. Darim joined the widow of his deceased brother and her children, which led to their bloodline integrating into the Egyptian Assassins.
By 1511, the Egyptian Assassins were under the leadership of their Mentor Iskender, a descendant of Altaïr Ibn-La'Ahad. He was captured to be executed that year, but was saved by Ottoman Assassins sent from Constantinople by the Mentor of the Italian Assassins, Ezio Auditore da Firenze.
By 1794, the Egyptian Assassins were led by an individual who was known as Al Mualim, who was based in Cairo. Arno Dorian sent one of his fellow French Assassins to the city with the Apple of Eden he had taken from the Head of Saint Denis to keep it safe.