- "Futile murder... beautiful death. She... will make you suffer."
- ―Vázquez's last words, 1776.[src]
Working for Madeleine de L'Isle, otherwise known as the "Company Man", Vázquez was sent to the city during the 1770s to take control of the Louisiana Bayou. To realize this, he gathered a large number of men, winning their loyalty through bribery.
Bribing the Spanish
- "Twice, recruiters have approached me, claiming to offer me promotion if I'll serve in his secret unit. But I don't trust it, no Señor!"
- ―A guard on Vázquez's recruiters, 1776.[src]
Having tracked down and eliminated one of Vázquez's recruiters, Aveline learned of the Templar's plans and subsequently went to warn her Mentor Agaté, who was based in the bayou. On his instruction, she made a patrol believe they had become the victim of a voodoo curse, which temporarily set back Vázquez's progress.
Around the same time, Vázquez made plans to retake the work site of Chichen Itza, which had been freed from the Templars' control following the death of Rafael Joaquín de Ferrer. To achieve this, he assigned a group of his men to divert a supply ship and use it to travel to Mexico. However, this scheme too was sabotaged by Aveline, who disabled the lighthouse on Lake Pontchartrain to make Vázquez's vessel run aground. Working together with the smugglers Élise Lafleur and Roussillon, she then plundered the supply ship's goods, finding documents aboard that led her to discover the Templar's plans for Chichen Itza.
Disrupting the smugglers' trade
That same year, Vázquez, having managed to evade detection by the Assassins for roughly five years, attended a prestigious ball at a plantation in New Orleans. Unbeknownst to him, Aveline was also present at the ball, having come to track down and assassinate the Templar. After mingling with the guests, she managed to locate Vázquez and approached him.
Charmed by her noble appearance, the Templar danced with Aveline and then allowed her to lead him to a quiet balcony, where he was stabbed. With his dying breath, Vázquez revealed that he was not the Company Man, as Aveline believed, and that it was actually a woman, but died before he could reveal her identity.
- Diego is the Spanish equivalent of James, a name of Hebrew origin meaning "he who supplants". Vázquez is a Spanish surname of Basque origins that means "son of Vasco", with Vasco being derived from the pre-Roman latinized "Velascus" - a name of uncertain origin and meaning.
- Unlike Aveline's other targets, Vázquez was not given an in-game database entry, nor did he have one in the Assassin's Creed Encyclopedia.
- There was a portrait of Vázquez in Davenport Homestead, visible in Assassin's Creed: Rogue.