In the hope of accomplishing a joint Moon landing, John F. Kennedy proposed a partnership with Soviet Russia which made him a target of the Templar Order and their public front, Abstergo Industries. The Templars also coveted Kennedy's Apple of Eden to add to the pair already in their possession.

While on a visit to Dallas, Texas in 1963, the 35th President of the United States was assassinated by an Abstergo sleeper agent. As panic engulfed the spectators, Kennedy's driver — a Templar plant — retrieved the deceased President's Apple. A Piece of Eden was also used to create a phantom on a nearby hill, in order to cause further confusion around the circumstances of Kennedy's death.