The Centro District (Center District) was one of the four districts of Rome during the Renaissance. This district was characterized by its large cityscape and tall buildings, being more densely populated than the rest of the city.
During the early 16th century, the Centro district, like the Antico and Campagna districts, fell into disrepair under the rule of the House of Borgia. They exerted their influence over the citizens of the district through five Borgia Towers, each guarded by a Borgia Captain.
By 1503, Ezio Auditore had burned down all of the Borgia towers and had re-opened most of the shops. He had also already re-established the Rosa in Fiore, and in turn, the Courtesans Guild, in order to aid him in his war against the Borgia.
The Centro district was the home of famous Roman landmarks, which include the Pantheon, the Mausoleo di Augusto and the Campidoglio. It is also where Tiber Island, the Assassins' stronghold, was located. Its portion across the river, a dilapidated and poor area, was known as Trastevere.
Centro is the only district that is adjacent to all three other districts – the Tiber river separates it from the Vaticano District, but it can be accessed via the Ponte Sant'Angelo or by gondola. Within this district, the following could be found:
- The Rosa in Fiore
- The Assassins Guild on Tiber Island
- Three Faction buildings
- Six banks
- Eight blacksmiths and one blacksmith shop quest
- Twenty-three doctors and one medical shop quest
- Six tailors and one tailor shop quest
- Five art merchants and one art merchant shop quest
- Five Borgia/Assassin Towers
- Eight pigeon coops
- Five tunnel entrances
- Three stables
- Mausoleo di Augusto
- Palazzo Senatorio
- The Centro district was the only district that did not feature any lairs of Romulus.